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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Silicon Switches of Marketed Drugs

Author(s): P. K. Pooni and G. A. Showell

Volume 6, Issue 10, 2006

Page: [1169 - 1177] Pages: 9

DOI: 10.2174/138955706778560120

Price: $65

Abstract

The application of organosilicon chemistry is a strategy to develop best in class drugs applied to targets that have been validated as tractable and drug-able. Silicon switches of known drugs have been synthesised and evaluated in biological assay systems then compared to their marketed all-carbon counterparts. Recent examples include the silicon switches of drugs haloperidol, fexofenadine, bexarotene and venlafaxine.

Keywords: Organosilicon chemistry, silicon switch, marketed drugs, validated targets

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