Abstract
Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from triacylglycerol (TG) stores during intracellular lipolysis producing FAs used for energy production. There is growing evidence that the products and intermediates from lipolytic breakdown during the FA mobilization process also have fundamental regulatory functions affecting cell signaling, gene expression, metabolism, cell growth, cell death, and lipotoxicity. Regulation of ATGL is therefore vital for maintaining a defined balance between lipid storage and mobilization. This review addresses the regulation of ATGL activity at the post-translational level with special emphasis on protein-mediated interaction at the site of hydrolytic action, namely to the lipid droplet.
Keywords: Lipolysis, ATGL, adipose triglyceride lipase, PNPLA2, patatin-like phospholipase domain-containing protein 2, G0S2, G0/G1 switch gene 2, CGI-58, comparative gene identification 58, ABHD5, α/β hydrolase domain containing protein 5, perilipin, Plin, cell death activator CIDE-3, CIDEC, fat-specific protein 27, FSP27, hypoxia-inducible lipid dropleT-associated, HILPDA, pigment epithelium derived factor, PEDF, serpin family F member 1, SERPINF1, oleoyl-CoA, Atglistatin.
Current Protein & Peptide Science
Title:Adipose Triglyceride Lipase Regulation: An Overview
Volume: 19 Issue: 2
Author(s): Ines Katrin Cerk, Lisa Wechselberger and Monika Oberer*
Affiliation:
- Institute of Molecular Biosciences, BioTechMed Graz, University of Graz, A-8010 Graz,Austria
Keywords: Lipolysis, ATGL, adipose triglyceride lipase, PNPLA2, patatin-like phospholipase domain-containing protein 2, G0S2, G0/G1 switch gene 2, CGI-58, comparative gene identification 58, ABHD5, α/β hydrolase domain containing protein 5, perilipin, Plin, cell death activator CIDE-3, CIDEC, fat-specific protein 27, FSP27, hypoxia-inducible lipid dropleT-associated, HILPDA, pigment epithelium derived factor, PEDF, serpin family F member 1, SERPINF1, oleoyl-CoA, Atglistatin.
Abstract: Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from triacylglycerol (TG) stores during intracellular lipolysis producing FAs used for energy production. There is growing evidence that the products and intermediates from lipolytic breakdown during the FA mobilization process also have fundamental regulatory functions affecting cell signaling, gene expression, metabolism, cell growth, cell death, and lipotoxicity. Regulation of ATGL is therefore vital for maintaining a defined balance between lipid storage and mobilization. This review addresses the regulation of ATGL activity at the post-translational level with special emphasis on protein-mediated interaction at the site of hydrolytic action, namely to the lipid droplet.
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Cite this article as:
Cerk Katrin Ines , Wechselberger Lisa and Oberer Monika *, Adipose Triglyceride Lipase Regulation: An Overview, Current Protein & Peptide Science 2018; 19 (2) . https://dx.doi.org/10.2174/1389203718666170918160110
DOI https://dx.doi.org/10.2174/1389203718666170918160110 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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