Abstract
Organically modified silica (Ormosil) gels are three-dimensional matrices obtained by co-polymerizing tetraalkyl orthosilicates and organoalkoxysilanes through the sol-gel technology. Ormosil matrices are highly flexible with respect to macroscopic size and shape, as they can be prepared in the form of monoliths, layers, powders and nanoparticles, and to their physical-chemical properties, with special regard to hydrophobicity or specific functionalization of their alkyl and aryl groups. This makes Ormosils a very promising matrix, though not widely exploited so far, for the immobilization of enzymes and other biomolecules either by encapsulation within the gel matrix or by surface decoration of nanoparticles. Potential applications range from the development of biocatalysts and bioremediation devices to intracellular drug delivery and photodynamic therapy.
Keywords: Organically modified silica, enzyme immobilization, surface decoration, bioremediation.
Current Organic Chemistry
Title:Immobilization of Proteins in Ormosil Gels: Functional Properties and Applications
Volume: 19 Issue: 17
Author(s): Luca Ronda, Stefano Bettati and Stefano Bruno
Affiliation:
Keywords: Organically modified silica, enzyme immobilization, surface decoration, bioremediation.
Abstract: Organically modified silica (Ormosil) gels are three-dimensional matrices obtained by co-polymerizing tetraalkyl orthosilicates and organoalkoxysilanes through the sol-gel technology. Ormosil matrices are highly flexible with respect to macroscopic size and shape, as they can be prepared in the form of monoliths, layers, powders and nanoparticles, and to their physical-chemical properties, with special regard to hydrophobicity or specific functionalization of their alkyl and aryl groups. This makes Ormosils a very promising matrix, though not widely exploited so far, for the immobilization of enzymes and other biomolecules either by encapsulation within the gel matrix or by surface decoration of nanoparticles. Potential applications range from the development of biocatalysts and bioremediation devices to intracellular drug delivery and photodynamic therapy.
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Cite this article as:
Ronda Luca, Bettati Stefano and Bruno Stefano, Immobilization of Proteins in Ormosil Gels: Functional Properties and Applications, Current Organic Chemistry 2015; 19 (17) . https://dx.doi.org/10.2174/1385272819666150429232239
DOI https://dx.doi.org/10.2174/1385272819666150429232239 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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