Abstract
Recent studies have centred on 1,2-diazines derivatives, which proved to be invaluable materials in the fields of medicine, opto-electronics and agriculture. 1,2-diazines were found to have pharmaceutical applications including a wide range of biological activities, such as antiviral and anticancer, antituberculosis, antimicrobials, antifungus, anti-inflammatory, antihypertensive, diuretics, antithrombics, anticoagulants, antidepressant, anxiolytics, anticonvulsant, analgesic, and anti-multiple sclerosis. Their applications in the field of electronics are mainly focused on highly fluorescent derivatives (with potential as sensors and biosensors, electroluminescent materials, lasers, and other semiconductor devices) and compounds with liquid crystal properties. Herbicidal activity and the grow up factor for plants are also reviewed.
Microwave assisted organic synthesis (MAOS) has during the last years become an invaluable tool within chemistry research, which has shown to be a very efficient way towards the synthesis of many compounds.
In this review, microwave assisted reactions of 1,2-diazine derivatives have been discussed, outlining an introduction to MW chemistry, N-alkylations, dipolar cycloadditions, cyclocondensations, transition-metal catalysed reactions, and nucleophilic substitution of 1,2- diazines.
Keywords: Pyridazine, phthalazine, microwave, biological activity, fluorescence, herbicides, grow up factors
Current Organic Chemistry
Title: Recent Achievements in the Chemistry of 1,2-Diazines
Volume: 15 Issue: 5
Author(s): Ionel I. Mangalagiu
Affiliation:
Keywords: Pyridazine, phthalazine, microwave, biological activity, fluorescence, herbicides, grow up factors
Abstract: Recent studies have centred on 1,2-diazines derivatives, which proved to be invaluable materials in the fields of medicine, opto-electronics and agriculture. 1,2-diazines were found to have pharmaceutical applications including a wide range of biological activities, such as antiviral and anticancer, antituberculosis, antimicrobials, antifungus, anti-inflammatory, antihypertensive, diuretics, antithrombics, anticoagulants, antidepressant, anxiolytics, anticonvulsant, analgesic, and anti-multiple sclerosis. Their applications in the field of electronics are mainly focused on highly fluorescent derivatives (with potential as sensors and biosensors, electroluminescent materials, lasers, and other semiconductor devices) and compounds with liquid crystal properties. Herbicidal activity and the grow up factor for plants are also reviewed.
Microwave assisted organic synthesis (MAOS) has during the last years become an invaluable tool within chemistry research, which has shown to be a very efficient way towards the synthesis of many compounds.
In this review, microwave assisted reactions of 1,2-diazine derivatives have been discussed, outlining an introduction to MW chemistry, N-alkylations, dipolar cycloadditions, cyclocondensations, transition-metal catalysed reactions, and nucleophilic substitution of 1,2- diazines.
Export Options
About this article
Cite this article as:
I. Mangalagiu Ionel, Recent Achievements in the Chemistry of 1,2-Diazines, Current Organic Chemistry 2011; 15 (5) . https://dx.doi.org/10.2174/138527211794519050
DOI https://dx.doi.org/10.2174/138527211794519050 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Genetic Surgery - A Right Strategy to Attack Cancer
Current Gene Therapy Therapeutic Strategies for Targeting BRAF in Human Cancer
Reviews on Recent Clinical Trials Protectors of the Mitochondrial Permeability Transition Pore Activated by Iron and Doxorubicin
Current Cancer Drug Targets Death Receptor Ligands: New Strategies for Combined Treatment with Ionizing Radiation
Current Medicinal Chemistry - Anti-Cancer Agents Inflammation and Pancreatic Cancer: Recent Development with Focusing on Potential New Drug Targets
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Plant Ribonucleases and Nucleases as Antiproliferative Agens Targeting Human Tumors Growing in Mice
Recent Patents on DNA & Gene Sequences Stem Cell Transplantation for Hematological Malignancies: Prospects for Personalized Medicine and Co-therapy with Mesenchymal Stem Cells
Current Pharmacogenomics and Personalized Medicine Fyn Kinase in Brain Diseases and Cancer: The Search for Inhibitors
Current Medicinal Chemistry The Role of Systemic Treatment and Radiotherapy in Malignant Mesothelioma
Current Respiratory Medicine Reviews Targeted Tumor Therapies at a Glance
Current Drug Targets Decreasing the Metastatic Potential in Cancers - Targeting the Heparan Sulfate Proteoglycans
Current Drug Targets Subject Index to Volume 4
Current Medicinal Chemistry - Anti-Cancer Agents Current Status and Future Directions of Nanoparticulate Strategy for Cancer Immunotherapy
Current Drug Metabolism Nicotine, Lung and Cancer
Anti-Cancer Agents in Medicinal Chemistry Mutations of Chromatin Structure Regulating Genes in Human Malignancies
Current Protein & Peptide Science Investigating the In Vivo Expression Patterns of miR-7 microRNA Family Members in the Adult Mouse Brain
MicroRNA Immune Checkpoint Regulators: A New Era Toward Promising Cancer Therapy
Current Cancer Drug Targets Editorial [Hot Topic: Inflammation as Target for Pharmaceutical Intervention in Cancer (Executive Editors: R.M. Schiffelers and K.E. de Visser)]
Current Pharmaceutical Design Carbon Nanotubes – Curse or Blessing
Current Medicinal Chemistry Efficacy and Safety of the Combination of Docetaxel (Taxotere®) with Targeted Therapies in the Treatment of Solid Malignancies
Current Drug Targets