Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

A Snapshot of Tissue Glycerolipids

Author(s): Amina S. Woods, Hay-Yan J. Wang and Shelley N. Jackson

Volume 13, Issue 32, 2007

Page: [3344 - 3356] Pages: 13

DOI: 10.2174/138161207782360636

Price: $65

Abstract

The lipid membrane is the portal to the cell and its first line of defense against the outside world. Its plasticity, diversity and powers of accommodation in a myriad of environments, mirrored by the varied make up of the cells it protects, are unparalleled. Glycerophospholipids are one of its major components. In cell membranes the extracellular layer is mainly made up of positively charged glycolipids, while the intracellular ones main components are negatively charged. Advances in mass spectrometry have allowed the direct probing of tissues, and thus a direct approach to probing membranes make up was developed. Until recently most studies have focused on proteins. An overview of the use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) for the direct analysis of phospholipids in various tissue is presented. Molecular ions corresponding to phosphatidylcholines, sphingomyelin, phosphatidylethanolamines, phosphatidylserines, phosphatidylinositols and sulfatides were mapped.

Keywords: phosphocholine head group, phosphatidylethanolamines, fragment peaks, MALDI, Lipid

« Previous

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy