Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Severe Alcoholic Hepatitis Effectively Treated with Vitamin E as an Add-on to Corticosteroids
Yuichi MiyashimaMichihiko ShibataYuichi HonmaHidehiko MatsuokaMasaaki HiuraShintaro AbeMasaru Harada
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JOURNAL OPEN ACCESS

2017 Volume 56 Issue 24 Pages 3293-3297

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Abstract

A 49-year-old woman with a history of heavy alcohol drinking was admitted to our hospital due to jaundice and abdominal distention. A blood test showed leukophilia, mild hypoalbuminemia, hyperbilirubinemia, hepatobiliary injury and coagulopathy. Image studies showed an extremely enlarged fatty liver and splenomegaly. The Japan alcoholic hepatitis score and Maddrey's discriminant function were 10 and 54 points, respectively. We diagnosed her with severe alcoholic hepatitis and treated her with corticosteroids, but her liver function did not improve. We therefore administered the vitamin E product tochopheryl acetate (150 mg/day) as an add-on therapy, after which her leukophilia, liver enzymes and coagulopathy improved immediately.

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© 2017 by The Japanese Society of Internal Medicine
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