Scedosporium prolificans Endocarditis: Case Report and Literature Review

Yoshitaka Wakabayashi; Shu Okugawa; Keita Tatsuno; Mahoko Ikeda; Yoshiki Misawa; Saho Koyano; Eiichi Tsuji; Shintaro Yanagimoto; Shuji Hatakeyama; Kyoji Moriya; Hiroshi Yotsuyanagi

doi:10.2169/internalmedicine.55.5592

CASE REPORTS

Scedosporium prolificans Endocarditis: Case Report and Literature Review

Yoshitaka Wakabayashi, Shu Okugawa, Keita Tatsuno, Mahoko Ikeda, Yoshiki Misawa, Saho Koyano, Eiichi Tsuji, Shintaro Yanagimoto, Shuji Hatakeyama, Kyoji Moriya, Hiroshi Yotsuyanagi

Author information

Yoshitaka Wakabayashi
Department of Infectious Diseases, The University of Tokyo, Japan
Shu Okugawa
Department of Infectious Diseases, The University of Tokyo, Japan
Department of Infection Control and Prevention, The University of Tokyo, Japan
Keita Tatsuno
Department of Infectious Diseases, The University of Tokyo, Japan
Department of Infection Control and Prevention, The University of Tokyo, Japan
Mahoko Ikeda
Department of Infectious Diseases, The University of Tokyo, Japan
Department of Infection Control and Prevention, The University of Tokyo, Japan
Yoshiki Misawa
Department of Infection Control and Prevention, The University of Tokyo, Japan
Saho Koyano
Department of Infection Control and Prevention, The University of Tokyo, Japan
Eiichi Tsuji
Department of Gastrointestinal Surgery, Metabolic Care and Endocrine Surgery, The University of Tokyo Hospital, Japan
Shintaro Yanagimoto
Department of Infectious Diseases, The University of Tokyo, Japan
Shuji Hatakeyama
Department of Infectious Diseases, The University of Tokyo, Japan
Kyoji Moriya
Department of Infection Control and Prevention, The University of Tokyo, Japan
Hiroshi Yotsuyanagi
Department of Infectious Diseases, The University of Tokyo, Japan

Keywords: Scedosporium prolificans, Endocarditis, β-D glucan, fungal infection

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 1 Pages 79-82

DOI https://doi.org/10.2169/internalmedicine.55.5592

Details

Abstract

Scedosporium prolificans, a hyaline filamentous fungus, is widely distributed in the environment and is currently an emerging human pathogen, especially among immunocompromised patients. However, S. prolificans endocarditis is rare. We herein report a case of S. prolificans endocarditis in a 64-year-old patient with breast cancer in complete remission for 30 years after chemotherapy and radiation treatment who was not cured. Susceptibility testing showed resistance to all antifungal drugs, except echinocandin. A review of the literature revealed 10 cases of S. prolificans endocarditis; of these, only one involved an immunocompetent host with no risk factors and only two patients survived. In order to improve the mortality rate, it is necessary to establish rapid diagnostic methods and efficient therapeutic approaches.

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