Malignant Peripheral Nerve Sheath Tumor of the Liver

Satoru Kakizaki; Norio Horiguchi; Toshiyuki Otsuka; Daichi Takizawa; Yuichi Yamazaki; Ken Sato; Yoshihiro Ohno; Motoyasu Kusano; Masanobu Yamada

doi:10.2169/internalmedicine.55.5456

CASE REPORTS

Malignant Peripheral Nerve Sheath Tumor of the Liver

Satoru Kakizaki, Norio Horiguchi, Toshiyuki Otsuka, Daichi Takizawa, Yuichi Yamazaki, Ken Sato, Yoshihiro Ohno, Motoyasu Kusano, Masanobu Yamada

Author information

Satoru Kakizaki
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
Norio Horiguchi
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
Department of Internal Medicine, Tone-Chuo Hospital, Japan
Toshiyuki Otsuka
Department of Internal Medicine, Tone-Chuo Hospital, Japan
Daichi Takizawa
Department of Internal Medicine, Tone-Chuo Hospital, Japan
Yuichi Yamazaki
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
Ken Sato
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
Yoshihiro Ohno
Department of Pathology, Tone-Chuo Hospital, Japan
Motoyasu Kusano
Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Japan
Masanobu Yamada
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan

Keywords: malignant peripheral nerve sheath tumor, malignant schwannoma

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 3 Pages 245-249

DOI https://doi.org/10.2169/internalmedicine.55.5456

Details

Abstract

Malignant peripheral nerve sheath tumor (MPNST) of the liver is rare. Most cases of MPNST are accompanied by neurofibromatosis 1 (NF-1, von Recklinghausen's disease). We herein report an autopsy case of MPNST without NF-1 and review the pertinent literature. The tumor occupied the entire lobe of the liver, and was 18 cm in maximum diameter. The tumor revealed necrosis and cystic changes with hemorrhage and it had also metastasized to the peritoneum. Microscopically, the tumor was composed of pleomorphic spindle cells with hyperchromatic nuclei and mitogenic figures. The spindle cells stained positive for both S-100 and vimentin antibodies.

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