Small Cell Lung Cancer Expressing Glutamate Decarboxylase with Latent Autoimmune Diabetes in Adults

Takanori Asakura; Shuichi Yoshida; Arafumi Maeshima; Kazuyuki Fujimoto; Rie Jo; Kyoko Iwase; Yoshitaka Oyamada

doi:10.2169/internalmedicine.54.4478

CASE REPORTS

Small Cell Lung Cancer Expressing Glutamate Decarboxylase with Latent Autoimmune Diabetes in Adults

Takanori Asakura, Shuichi Yoshida, Arafumi Maeshima, Kazuyuki Fujimoto, Rie Jo, Kyoko Iwase, Yoshitaka Oyamada

Author information

Keywords: small cell lung cancer, glutamate decarboxylase, diabetes mellitus, paraneoplastic syndrome, latent autoimmune diabetes in adults

JOURNAL OPEN ACCESS

2015 Volume 54 Issue 23 Pages 3035-3037

DOI https://doi.org/10.2169/internalmedicine.54.4478

Details

Abstract

Small cell lung cancer (SCLC) causes paraneoplastic syndromes, such as diabetes mellitus, by eliciting the expression of various antibodies including anti-glutamate decarboxylase (GAD) antibody. A 62-year-old woman presented to our hospital with a 1-week history of progressive dyspnea and difficulty in walking. Computed tomography showed a tumor obstructing the left bronchus and obstructive lung abscesses with pleural effusions. A biopsy during bronchoscopy revealed SCLC, and the clinical stage was ultimately determined to be IIIB. SCLC was complicated by diabetes mellitus with high titers of serum anti-GAD antibody. An immunohistochemical analysis showed GAD expression in the cancer cells, which is a novel finding.

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