Tubulointerstitial Nephritis and Primary Biliary Cirrhosis with a T Cell-dominant Profile of Infiltrating Cells and Granulomas in Both Organs

Takamasa Iwakura; Yoshihide Fujigaki; Takashi Matsuyama; Tomoyuki Fujikura; Naro Ohashi; Hideo Yasuda; Akihiko Kato; Satoshi Baba

doi:10.2169/internalmedicine.52.9003

CASE REPORTS

Tubulointerstitial Nephritis and Primary Biliary Cirrhosis with a T Cell-dominant Profile of Infiltrating Cells and Granulomas in Both Organs

Takamasa Iwakura, Yoshihide Fujigaki, Takashi Matsuyama, Tomoyuki Fujikura, Naro Ohashi, Hideo Yasuda, Akihiko Kato, Satoshi Baba

Author information

Takamasa Iwakura
Internal Medicine I, Division of Nephrology, Hamamatsu University School of Medicine, Japan
Yoshihide Fujigaki
Internal Medicine I, Division of Nephrology, Hamamatsu University School of Medicine, Japan
Takashi Matsuyama
Internal Medicine I, Division of Nephrology, Hamamatsu University School of Medicine, Japan
Tomoyuki Fujikura
Internal Medicine I, Division of Nephrology, Hamamatsu University School of Medicine, Japan
Naro Ohashi
Internal Medicine I, Division of Nephrology, Hamamatsu University School of Medicine, Japan
Hideo Yasuda
Internal Medicine I, Division of Nephrology, Hamamatsu University School of Medicine, Japan
Akihiko Kato
Blood Purification Unit, Hamamatsu University School of Medicine, Japan
Satoshi Baba
Department of Pathology, Hamamatsu University School of Medicine, Japan

Keywords: interstitial nephritis, granuloma, primary biliary cirrhosis

JOURNAL OPEN ACCESS

2013 Volume 52 Issue 4 Pages 467-471

DOI https://doi.org/10.2169/internalmedicine.52.9003

Details

Abstract

A 46-year-old woman was admitted to our hospital for an evaluation of progressive renal insufficiency and elevated liver enzymes. A renal biopsy revealed chronic granulomatous interstitial nephritis. Her laboratory findings indicated primary biliary cirrhosis (PBC), which was confirmed with a liver biopsy. CD4⁺ T cells and CD8⁺ T cells with granuloma formation were the predominant cells infiltrating into the interstitium of the kidneys and liver. The etiology of tubulointerstitial nephritis in the present patient was not clear; however, it might have shared the same pathogenesis as PBC due to the relatively close onset, the similar profiles of infiltrating cells and the presence of granulomas.

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