Skip to main content
Log in

Population Pharmacokinetic/Pharmacodynamic Analyses as the Basis for Dosing of Therapeutic Monoclonal Antibodies

  • Commentary
  • Published:
Clinical Pharmacokinetics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Zhang L, Pfister M, Meibohm B. Concepts and challenges in quantitative pharmacology and model-based drug development. AAPS J 2008; 10(4): 552–9

    Article  PubMed  CAS  Google Scholar 

  2. Sutjandra L, Rodriguez RD, Doshi S, et al. Population pharmacokinetic meta-analysis of denosumab in healthy subjects and postmenopausal women with osteopenia or osteoporosis. Clin Pharmacokinet 2011; 50(12): 793–807

    Article  PubMed  CAS  Google Scholar 

  3. Gibiansky L, Gibiansky E, Kakkar T, et al. Approximations of the target-mediated drug disposition model and identifiability of model parameters. J Pharmacokinet Pharmacodyn 2008; 35(5): 573–91

    Article  PubMed  CAS  Google Scholar 

  4. Dirks NL, Meibohm B. Population pharmacokinetics of therapeutic monoclonal antibodies. Clin Pharmacokinet 2010; 49(10): 633–59

    Article  PubMed  CAS  Google Scholar 

  5. Wang DD, Zhang S, Zhao H, et al. Fixed dosing versus body size-based dosing of monoclonal antibodies in adult clinical trials. J Clin Pharmacol 2009; 49(9): 1012–24

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

No sources of funding were used in the preparation of this commentary. The author has no conflicts of interest that are directly relevant to the content of this commentary.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bernd Meibohm.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Meibohm, B. Population Pharmacokinetic/Pharmacodynamic Analyses as the Basis for Dosing of Therapeutic Monoclonal Antibodies. Clin Pharmacokinet 50, 823–824 (2011). https://doi.org/10.2165/11597950-000000000-00000

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/11597950-000000000-00000

Keywords

Navigation