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Autoimmune Hepatitis Induced by Infliximab in a Patient with Crohn’s Disease with no Relapse After Switching to Adalimumab

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Abstract

Infliximab and adalimumab are anti-tumor necrosis factor (TNF) alpha agents used for treating Crohn’s disease. Autoimmune hepatitis (AIH) is a rare complication of treatment with these drugs. We report on a case of AIH in a patient with Crohn’s disease treated with infliximab who fully recovered after drug withdrawal. More interestingly, because there were no other treatment options, the patient was then treated with adalimumab without recurrence of the liver disease and with control of the intestinal disease.

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Acknowledgments

Professor Cravo received honoraria for the submission of the case report, which was funded by Schering-Plough/MSD Portugal. The other authors declare no potential conflicts of interest relevant to this case report.

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Authors and Affiliations

  1. Gastroenterology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Rua Professor Lima Basto, 1099-023, Lisbon, Portugal

    Marilia Cravo & Miguel Serrano

  2. Gastroenterology Department, Hospital Central do Funchal, Madeira, Portugal

    Rosa Silva

Authors
  1. Marilia Cravo
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  2. Rosa Silva
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  3. Miguel Serrano
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Correspondence to Marilia Cravo.

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Cravo, M., Silva, R. & Serrano, M. Autoimmune Hepatitis Induced by Infliximab in a Patient with Crohn’s Disease with no Relapse After Switching to Adalimumab. BioDrugs 24 (Suppl 1), 25–27 (2010). https://doi.org/10.2165/11586210-000000000-00000

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  • DOI: https://doi.org/10.2165/11586210-000000000-00000

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