Abstract
Human herpesvirus 7 (HHV-7) was discovered in 1989 as a new member of the ß-herpesvirus subfamily. Primary infection occurs early in life and manifests as exanthema subitum, or other febrile illnesses mimicking measles and rubella. Thus, HHV-7 has to be considered as a causative agent in a variety of macular-papular rashes in children. In addition, HHV-7 was found in some cases of other inflammatory skin disorders, such as psoriasis. There are controversial data on the detection of HHV-7 in pityriasis rosea, but so far there is not enough evidence for a pathogenetic association of HHV-7 with this exanthematic skin disease. Although HHV-7 can be found in some cases of Hodgkin’s disease, there are no data supporting a direct causative role in this lymphoma type nor in other nodal or primary cutaneous lymphomas. In various epidemiologic forms of Kaposi’s sarcoma, infection of monocytic cells with HHV-7 was demonstrated, which may indirectly influence tumor biology. In the context of immunosuppression, HHV-7 has recently been identified as an emerging pathogen in transplant recipients and may exacerbate graft rejection in renal transplant recipients. The ability of HHV-7 to induce cytokine production in infected cells could make HHV-7 an important pathogenetic co-factor in inflammatory and neoplastic disorders. Moreover, the restricted cellular tropism of HHV-7 may render this virus an interesting vector for gene therapy. Thirteen years after the discovery of HHV-7, there has been considerable progress in characterizing its genetic structure, virus-induced effects on infected host cells and in the development of diagnostic tools. Nevertheless, the role of HHV-7 in various skin diseases and the clinical manifestations of reactivation of HHV-7 infection have still to be defined.
Similar content being viewed by others
References
Black J.B., Pellett P.E. Human herpesvirus 7. Rev Med Virol 1999; 9: 245–262
Torigoe S., Kumamoto T., Koide W., et al. Clinical manifestations associated with human herpesvirus 7 infection. Arch Dis Child 1995; 72: 518–519
Black J.B., Durigon E., Kite Powell K., et al. Seroconversion to human herpesvirus 6 and human herpesvirus 7 among Brazilian children with clinical diagnoses of measles or rubella. Clin Infect Dis 1996; 23: 1156–1158
Caserta M.T., Hall C.B., Schnabel K., et al. Primary human herpesvirus 7 infection: a comparison of human herpesvirus 7 and human herpesvirus 6 infections in children. J Pediatr 1998; 133: 386–389
Frenkel N., Schirmer E.C., Wyatt L.S., et al. Isolation of a new herpesvirus from human CD4+ T cells. Proc Natl Acad Sci U S A 1990; 87: 748–752
Berneman Z.N., Ablashi D.V., Li G., et al. Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus. Proc Natl Acad Sci U S A 1992; 89: 10552–10556
Nicholas J. Determination and analysis of the complete nucleotide sequence of human herpesvirus. J Virol 1996; 70: 5975–5989
Singer O., Frenkel N. Human herpesvirus 7 (HHV-7) DNA: analyses of clones spanning the entire genome. Arch Virol 1997; 142: 287–303
Berneman Z.N., Gallo R.C., Ablashi D.V., et al. Human herpesvirus 7 (HHV-7) strain JI: independent confirmation of HHV-7. J Infect Dis 1992; 166: 690–691
Black J.B., Burns D.A., Goldsmith C.S., et al. Biologic properties of human herpesvirus 7 strain SB. Virus Res 1997; 52: 25–41
Secchiero P., Berneman Z.N., Gallo R.C., et al. Biological and molecular characteristics of human herpesvirus 7: in vitro growth optimization and development of a syncytia inhibition test. Virology 1994; 202: 506–512
Cermelli C., Pietrosemoli P., Meacci M., et al. SupT-1: a cell system suitable for an efficient propagation of both HHV-7 and HHV-6 variants A and B. New Microbiol 1997; 20: 187–196
Lusso P., Secchiero P., Crowley R.W., et al. CD4 is a critical component of the receptor for human herpesvirus 7: interference with human immunodeficiency virus. Proc Natl Acad Sci U S A 1994; 91: 3872–3876
Furukawa M., Yasukawa M., Yakushijin Y., et al. Distinct effects of human herpesvirus 6 and human herpesvirus 7 on surface molecule expression and function of CD4+ T cells. J Immunol 1994; 152: 5768–5775
Crowley R.W., Secchiero P., Zella D., et al. Interference between human herpesvirus 7 and HIV-1 in mononuclear phagocytes. J Immunol 1996; 156: 2004–2008
Kempf W., Adams V., Wey N., et al. CD68+ cells of monocyte/macrophage lineage in the environment of AIDS-associated and classic-sporadic Kaposi sarcoma are singly or doubly infected with human herpesviruses 7 and 6B. Proc Natl Acad Sci U S A 1997; 94: 7600–7605
Wyatt L.S., Frenkel N. Human herpesvirus 7 is a constitutive inhabitant of adult human saliva. J Virol 1992; 66: 3206–3209
Hidaka Y., Liu Y., Yamamoto M., et al. Frequent isolation of human herpesvirus 7 from saliva samples. J Med Virol 1993; 40: 343–346
Fujisaki H., Tanaka Taya K., Tanabe H., et al. Detection of human herpesvirus 7 (HHV- 7) DNA in breast milk by polymerase chain reaction and prevalence of HHV-7 antibody in breast-fed and bottle-fed children. J Med Virol 1998; 56: 275–279
Takahashi Y., Yamada M., Nakamura J., et al. Transmission of human herpesvirus 7 through multigenerational families in the same household. Pediatr Infect Dis J 1997; 16: 975–978
Tanaka Taya K., Kondo T., Mukai T., et al. Seroepidemiological study of human herpesvirus-6 and -7 in children of different ages and detection of these two viruses in throat swabs by polymerase chain reaction. J Med Virol 1996; 48: 88–94
Huang L.M., Lee C.Y., Liu M.Y., et al. Primary infections of human herpesvirus-7 and herpesvirus-6: a comparative, longitudinal study up to 6 years of age. Acta Paediatr 1997; 86: 604–608
Asano Y., Suga S., Yoshikawa T., et al. Clinical features and viral excretion in an infant with primary human herpesvirus 7 infection. Pediatrics 1995; 95: 187–190
Katsafanas G.C., Schirmer E.C., Wyatt L.S., et al. In vitro activation of human herpesviruses 6 and 7 from latency. Proc Natl Acad Sci U S A 1996; 93: 9788–9792
Sada E., Yasukawa M., Ito C., et al. Detection of human herpesvirus 6 and human herpesvirus 7 in the submandibular gland, parotid gland, and lip salivary gland by PCR. J Clin Microbiol 1996; 34: 2320–2321
Kempf W., Adams V., Mirandola P., et al. Persistence of human herpesvirus 7 in normal tissues detected by expression of a structural antigen. J Infect Dis 1998; 178: 841–845
Yasukawa M., Yakushijin Y., Furukawa M., et al. Specificity analysis of human CD4+ T-cell clones directed against human herpesvirus 6 (HHV-6), HHV-7, and human cytomegalovirus. J Virol 1993; 67: 6259–6264
Wilborn F., Schmidt C.A., Lorenz F., et al. Human herpesvirus type 7 in blood donors: detection by the polymerase chain reaction. J Med Virol 1995; 47: 65–69
Kidd I.M., Clark D.A., Ait Khaled M., et al. Measurement of human herpesvirus 7 load in peripheral blood and saliva of healthy subjects by quantitative polymerase chain reaction. J Infect Dis 1996; 174: 396–401
Black J.B., Schwarz T.F., Patton J.L., et al. Evaluation of immunoassays for detection of antibodies to human herpesvirus 7. Clin Diagn Lab Immunol 1996; 3: 79–83
Foa Tomasi L., Avitabile E., Ke L., et al. Polyvalent and monoclonal antibodies identify major immunogenic proteins specific for human herpesvirus 7-infected cells and have weak cross-reactivity with human herpesvirus 6. J Gen Virol 1994; 75: 2719–2727
Foa Tomasi L., Fiorilli M.P., Avitabile E., et al. Identification of an 85 kDa phosphoprotein as an immunodominant protein specific for human herpesvirus 7-infected cells. J Gen Virol 1996; 77: 511–518
Stefan A., Secchiero P., Baechi T., et al. The 85-kilodalton phosphoprotein (pp85) of human herpesvirus 7 is encoded by open reading frame U14 and localizes to a tegument substructure in virion particles. J Virol 1997; 71: 5758–5763
Black J.B., Schwarz T.F., Patton J.L., et al. Evaluation of immunoassays for detection of antibodies to human herpesvirus 7. Clin Diagn Lab Immunol 1996; 3: 79–83
Stefan A., De Lillo M., Frascaroli G., et al. Development of recombinant diagnostic reagents based on pp85 (U14) and p86(U11) proteins to detect the human immune response to human herpesvirus 7 infection. J Clin Microbiol 1999; 37: 3980–3985
Yamanishi K., Okuno T., Shiraki K., et al. Identification of human herpesvirus-6 as a causal agent for exanthema subitum. Lancet 1988; I: 1065–1067
Ueda K., Kusuhara K., Okada K., et al. Primary human herpesvirus 7 infection and exanthema subitum [letter]. Pediatr Infect Dis J 1994; 13: 167–168
Frenkel N., Wyatt L.S. HHV-6 and HHV-7 as exogenous agents in human lymphocytes. Dev Biol Stand 1992; 76: 259–265
Torigoe S., Koide W., Yamada M., et al. Human herpesvirus 7 infection associated with central nervous system manifestations. J Pediatr 1996; 129: 301–305
Chan P.K., Peiris J.S., Yuen K.Y., et al. Human herpesvirus-6 and human herpesvirus-7 infections in bone marrow transplant recipients. J Med Virol 1997; 53: 295–305
Bruns R., Muller C.E., Wiersbitzky S.K., et al. Clinical presentations of infection by the human herpesvirus-7 (HHV-7). Pediatr Hematol Oncol 2000; 17: 247–252
Chiu H.H., Lee C.Y., Lee P.I., et al. Mononucleosis syndrome and coincidental human herpesvirus-7 and Epstein-Barr virus infection. Arch Dis Child 1998; 78: 479–480
Kempf W., Burg G. Pityriasis rosea, a virus-induced skin disease: an update. Arch Virol 2000; 145: 1509–1520
Drago F., Ranieri E., Malaguti F., et al. Human herpesvirus 7 in patients with pityriasis rosea: electron microscopy investigations and polymerase chain reaction in mononuclear cells, plasma and skin. Dermatology 1997; 195: 374–378
Drago F., Ranieri E., Malaguti F., et al. Human herpesvirus 7 in patients with pityriasis rosea [letter]. Lancet 1997; 349: 1367
Watanabe T., Sugaya M., Nakamura K., et al. Human herpesvirus 7 and pityriasis rosea. J Invest Dermatol 1999; 113: 288–289
Yoshida M. Detection of human herpesvirus 7 in patients with pityriasis rosea and healthy individuals. Dermatology 1999; 199: 197–198
Lebbe C., Agbalika F. Pityriasis rosea and human herpesvirus 7, a true association [letter]? Dermatology 1998; 196: 275
Kempf W., Adams V., Kleinhans M., et al. Pityriasis rosea is not associated with human herpesvirus 7. Arch Dermatol 1999; 135: 1070–1072
Offidani A., Pritelli E., Simonetti O., et al. Pityriasis rosea associated with herpesvirus 7 DNA. J Eur Acad Dermatol Venereol 2000; 14: 313–314
Wong W.R., Tsai C.Y., Shih S.R., et al. Association of pityriasis rosea with human herpesvirus-6 and human herpesvirus-7 in Taipei. J Formos Med Assoc 2001; 100: 478–483
Yasukawa M., Sada E., MacHino H., et al. Reactivation of human herpesvirus 6 in pityriasis rosea. Br J Dermatol 1999; 140: 169–170
Kosuge H., Tanaka Taya K., Miyoshi H., et al. Epidemiological study of human herpesvirus-6 and human herpesvirus-7 in pityriasis rosea. Br J Dermatol 2000; 143: 795–798
Chuh A.A., Chiu S.S., Peiris J.S. Human herpesvirus 6 and 7 DNA in peripheral blood leucocytes and plasma in patients with pityriasis rosea by polymerase chain reaction: a prospective case control study. Acta Derm Venereol 2001; 81: 289–290
Chuh A.A., Peiris J.S. Lack of evidence of active human herpesvirus 7 (HHV-7) infection in three cases of pityriasis rosea in children. Pediatr Dermatol 2001; 18: 381–383
Ongradi J., Becker K., Horvath A., et al. Simultaneous infection by human herpesvirus 7 and human parvovirus B19 in papular-purpuric gloves-and-socks syndrome [letter]. Arch Dermatol 2000; 136: 672
Dockrell D.H., Paya C.V. Human herpesvirus-6 and -7 in transplantation. Rev Med Virol 2001; 11: 23–36
Osman H.K., Peiris J.S., Taylor C.E., et al. ‘Cytomegalovirus disease’ in renal allograft recipients: is human herpesvirus 7 a co-factor for disease progression? J Med Virol 1996; 48: 295–301
Tong C.Y., Bakran A., Williams H., et al. Association of human herpesvirus 7 with cytomegalovirus disease in renal transplant recipients. Transplantation 2000; 70: 213–216
Kidd I.M., Clark D.A., Sabin C.A., et al. Prospective study of human betaherpesviruses after renal transplantation: association of human herpesvirus 7 and cytomegalovirus co-infection with cytomegalovirus disease and increased rejection. Transplantation 2000; 69: 2400–2404
Chapenko S., Folkmane I., Tomsone V., et al. Co-infection of two beta-herpesviruses (CMV and HHV-7) as an increased risk factor for ‘CMV disease’ in patients undergoing renal transplantation. Clin Transplant 2000; 14: 486–492
Griffiths P.D., Ait Khaled M., Bearcroft C.P., et al. Human herpesviruses 6 and 7 as potential pathogens after liver transplant: prospective comparison with the effect of cytomegalovirus. J Med Virol 1999; 59: 496–501
Wang F.Z., Dahl H., Linde A., et al. Lymphotropic herpesviruses in allogeneic bone marrow transplantation. Blood 1996; 88: 3615–3620
Kempf W., Muller B., Maurer R., et al. Increased expression of human herpesvirus 7 in lymphoid organs of AIDS patients. J Clin Virol 2000; 16: 193–201
Di Luca D., Mirandola P., Ravaioli T., et al. Human herpesviruses 6 and 7 in salivary glands and shedding in saliva of healthy and human immunodeficiency virus positive individuals. J Med Virol 1995; 45: 462–468
Kidd I.M., Clark D.A., Aitkhaled M., et al. Measurement of human herpesvirus 7 load in peripheral blood and saliva of healthy subjects by quantitative polymerase chain reaction. J Infect Dis 1996; 174: 396–401
Schmidt C.A., Oettle H., Peng R., et al. Presence of human beta- and gamma-herpes virus DNA in Hodgkin’s disease. Leuk Res 2000; 24: 865–870
Secchiero P., Bonino L.D., Lusso P., et al. Human herpesvirus type 7 in Hodgkin’s disease. Br J Haematol 1998; 101: 492–499
Berneman Z.N., Torelli G., Luppi M., et al. Absence of a directly causative role for human herpesvirus 7 in human lymphoma and a review of human herpesvirus 6 in human malignancy. Ann Hematol 1998; 77: 275–278
Nagore E., Ledesma E., Collado C., et al. Detection of Epstein-Barr virus and human herpesvirus 7 and 8 genomes in primary cutaneous T- and B-cell lymphomas. Br J Dermatol 2000; 143: 320–323
Kempf W., Kadin M.E., Kutzner H., et al. Lymphomatoid papulosis and human herpesviruses: a PCR-based evaluation for the presence of human herpesvirus 6, 7 and 8 related herpesviruses. J Cutan Pathol 2001; 28: 29–33
Chang Y., Cesarman E., Pessin M.S., et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 1994; 266: 1865–1869
Antman K., Chang Y. Kaposi’s sarcoma. N Engl J Med 2000; 342: 1027–1038
Kempf W., Adams V. Viruses in the pathogenesis of Kaposi’s sarcoma: a review. Biochem Mol Med 1996; 58: 1–12
Drago F., Raineri E., Rebora A. Non-AIDS-related Kaposi sarcoma tissues do not contain DNA sequences of HHV-6, HHV-7, Epstein-Barr virus, cytomegalovirus and HSV. Acta Derm Venereol 1998; 78: 485
Atedzoe B.N., Menezes J., D’Addario M., et al. Modulatory effects of human herpes virus-7 on cytokine synthesis and cell proliferation in human peripheral blood mononuclear cell cultures. J Leukoc Biol 1999; 66: 822–828
Yoshida M., Yamada M., Tsukazaki T., et al. Comparison of antiviral compounds against human herpesvirus 6 and 7. Antiviral Res 1998; 40: 73–84
Brennan D.C., Storch G.A., Singer G.G., et al. The prevalence of human herpesvirus-7 in renal transplant recipients is unaffected by oral or intravenous ganciclovir. J Infect Dis 2000; 181: 1557–1561
Mendez J.C., Dockrell D.H., Espy M.J., et al. Human beta-herpesvirus interactions in solid organ transplant recipients. J Infect Dis 2001; 183: 179–184
Safrin S., Cherrington J., Jaffe H.S. Clinical use of cidofovir. Rev Med Virol 1997; 7: 73–84
Acknowledgments
The author declares no conflict of interest or financial support for the preparation of this manuscript.
Author information
Authors and Affiliations
Corresponding author
Additional information
This manuscript is dedicated to Prof. Gabriella Campadelli Fiume, University of Bologna, Bologna, Italy.
Rights and permissions
About this article
Cite this article
Kempf, W. Human Herpesvirus 7 in Dermatology. Am J Clin Dermatol 3, 309–315 (2002). https://doi.org/10.2165/00128071-200203050-00002
Published:
Issue Date:
DOI: https://doi.org/10.2165/00128071-200203050-00002