Approach to novel functional foods for stress control 3. Establishment of stress-resistant rat model and its mechanism

Yutaka Nakaya; Masaki Morishima-Yamato; Kaori Ishida; Nagakatsu Harada; Masayuki Nakano

doi:10.2152/jmi.52.244

Proceedings

Approach to novel functional foods for stress control
3. Establishment of stress-resistant rat model and its mechanism

Yutaka Nakaya, Masaki Morishima-Yamato, Kaori Ishida, Nagakatsu Harada, Masayuki Nakano

Author information

Keywords: exercise, hippocampus, monoamine oxidase A, stress

JOURNAL FREE ACCESS

2005 Volume 52 Issue Supplement Pages 244

DOI https://doi.org/10.2152/jmi.52.244

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Abstract

A stress-resistant rat model was introduced. SPORTS (Spontaneously-Running-Tokushima-Shikoku) rats showed significantly shorter time of immobility in the forced swim test compared to control Wister rats. Increase norepinephrine concentration secondary to decreased activity of monoamine oxidase A (MAOA) in hippocampus was observed in this model rats. This model rats are considered to be useful for studying the mechanism of psychological stress. J. Med. Invest. 52 Suppl.: 244, November, 2005

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