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Polymer-functionalized Gold Nanoparticles as Versatile Sensing Materials

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Abstract

In this brief review, gold nanoparticles conjugated with functional polymers are described from the viewpoint of application to sensing materials. The optical properties of gold nanoparticles, the synthesis of polymer-functionalized gold nanoparticles, and their analytical applications are discussed. Polymer-functionalized gold nanoparticles are categorized into two classes: biopolymer-conjugated gold nanoparticles and artificial-polymer conjugated gold nanoparticles. Fluorometric and colorimetric sensing using gold nanoparticles are focused; fluorometric detection enables us to exploit sensitive assays for practical use. Furthermore, chemical amplification using gold nanoparticles is also discussed for the sensitive probing.

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8 References

  1. G. Schmid, “Clusters and Colloids: From Theory to Applications”, 1994, Wiley-VCH, New York.

    Book  Google Scholar 

  2. “Nanomaterials for the Life Sciences”, ed. C. S. S. R. Kumer, 2009, Vol. 1, Wiley-VCH, New York.

  3. “Colloidal Nanoparticles in Biotechnology”, ed. A. Elaissari, 2008, Wiley-Interscience A John Wiley and Sons, New York.

  4. M. Faraday, Philosophical Transactions, 1857, 147, 145.

    Article  Google Scholar 

  5. M. J. N. Junk, R. Berger, and U. Jonas, Langmuir, 2010, 26, 7262.

    Article  CAS  PubMed  Google Scholar 

  6. M. E. Harmon, M. Tang, and C. W. Frank, Polymer, 2003, 44, 4547.

    Article  CAS  Google Scholar 

  7. A. Buguin, M.-H. Li, P. Silberzan, B. Ladoux, and P. Keller, J. Am. Chem. Soc, 2006, 128, 1088.

    Article  CAS  PubMed  Google Scholar 

  8. T. Saitoh, A. Sekino, and M. Hiraide, Chem. Lett., 2004, 33, 912.

    Article  CAS  Google Scholar 

  9. S. Dirk, Adv. Drug Delivery Rev., 2006, 58, 1655.

    Article  Google Scholar 

  10. M. Nakayama and T. Okano, J. Drug Delivery Sci. Technol., 2006, 16, 35.

    Article  CAS  Google Scholar 

  11. T. Nagaoka, H. Shiigi, and S. Tokonami, Bunseki Kagaku, 2007, 56, 201.

    Article  CAS  Google Scholar 

  12. M. T. Castañeda, S. Alegret, and A. Merkoci, Electroanalysis, 2007, 19, 743.

    Article  Google Scholar 

  13. S. Link and M. A. El-Sayed, J. Phys. Chem. B, 1999, 103, 8410.

    Article  CAS  Google Scholar 

  14. Z. Zhong, S. Patskovskyy, P. Bouvrette, J. H. T. Luong, and A. Gedanken, J. Phys. Chem. B, 2004, 108, 4046.

    Article  CAS  Google Scholar 

  15. W. Haiss, N. T. K. Thanh, J. Aveyard, and D. G. Fernig, Anal. Chem., 2007, 79, 4215.

    Article  CAS  PubMed  Google Scholar 

  16. N. G. Khlebtsov, Anal. Chem., 2008, 80, 6620.

    Article  CAS  PubMed  Google Scholar 

  17. P. N. Njoki, I.-I. S. Lim, D. Mott, H.-Y. Park, B. Khan, S. Mishra, R. Sujakumar, J. Luo, and C.-J. Zhong, J. Phys. Chem. C, 2007, 111, 14664.

    Article  CAS  Google Scholar 

  18. G. Gouesbet, J. Quant. Spectrosc. Radiat. Transfer, 2009, 110, 1223.

    Article  CAS  Google Scholar 

  19. C. M. Cobley, S. E. Skrabalak, D. J. Campbell, and Y. Xia, Plasmonics, 2009, 4, 171.

    Article  CAS  Google Scholar 

  20. C.-C. Huang, C.-K. Chiang, Z.-H. Lin, K.-H. Lee, and H.-T. Chang, Anal. Chem., 2008, 80, 1497.

    Article  CAS  PubMed  Google Scholar 

  21. C.-A. J. Lin, T.-Y. Yang, C.-H. Lee, S. H. Huang, R. A. Sperling, M. Zanella, J. K. Li, J.-L. Shen, H.-H. Wang, H.-I. Yeh, W. J. Parak, and W. H. Chang, ACS Nano, 2009, 3, 395.

    Article  Google Scholar 

  22. X. Liu, C. Li, J. Xu, J. Lv, M. Zhu, Y. Guo, S. Cui, H. Liu, S. Wang, and Y. Li, J. Phys. Chem. C, 2008, 112, 10778.

    Article  CAS  Google Scholar 

  23. H. He, C. Xie, and J. Ren, Anal. Chem., 2008, 80, 5951.

    Article  CAS  PubMed  Google Scholar 

  24. Q. Huo and J. G. Worden, J. Nanoparticle Res., 2007, 9, 1013.

    Article  CAS  Google Scholar 

  25. J. Shan and H. Tenhu, Chem. Commun., 2007, 4580.

  26. M. Kaholek, W.-K. Lee, S.-J. Ahn, H. Ma, K. C. Caster, B. LaMattina, and S. Zauscher, Chem. Mater., 2004, 16, 3688.

    Article  CAS  Google Scholar 

  27. W. Zhao, Y. Gao, S. A. Kandadai, M. A. Brook, and Y. Li, Angew. Chem., Int. Ed., 2006, 45, 2409.

    Article  CAS  Google Scholar 

  28. M. Higuchi, K. Ushiba, and M. Kawaguchi, J. Colloid Interface Sci., 2007, 308, 356.

    Article  CAS  PubMed  Google Scholar 

  29. Y. Liu, M. K. Shipton, J. Ryan, E. D. Kaufman, S. Franzen, and D. L. Feldheim, Anal. Chem., 2007, 79, 2221.

    Article  CAS  PubMed  Google Scholar 

  30. A. Aqil, H. Qiu, J.-F. Greisch, R. Jerome, E. D. Pauw, and C. Jerome, Polymer, 2008, 49, 1145.

    Article  CAS  Google Scholar 

  31. Z. Wang, B. Tan, I. Hussain, N. Schaeffer, M. F. Wyatt, M. Brust, and A. I. Cooper, Langmuir, 2007, 23, 885.

    Article  CAS  PubMed  Google Scholar 

  32. T. Sakai and P. Alexandridis, Langmuir, 2004, 20, 8426.

    Article  CAS  PubMed  Google Scholar 

  33. S. Yang, T. Zhang, L. Zhang, S. Wang, Z. Yang, and B. Ding, Colloids Surf., A, 2007, 296, 37.

    Article  CAS  Google Scholar 

  34. H. Dong, E. Fey, A. Gandelman, and W. E. Jones, Jr., Chem. Mater., 2006, 18, 2008.

    Article  CAS  Google Scholar 

  35. P. Zhang, X. Jiang, X. Zhang, W. Zhang, and L. Shi, Langmuir, 2006, 22, 9393.

    Article  PubMed  Google Scholar 

  36. M. Sakamoto, T. Tachikawa, M. Fujitsuka, and T. Majima, Langmuir, 2006, 22, 6361.

    Article  CAS  PubMed  Google Scholar 

  37. R. R. Bhattacharjee, M. Chakraborty, and T. K. Mandal, J. Phys. Chem. B, 2006, 110, 6768.

    Article  CAS  PubMed  Google Scholar 

  38. C. Note, S. Kosmella, and J. Koetz, Colloids Surf., A, 2006, 290, 150.

    Article  CAS  Google Scholar 

  39. H. Chen, Y. Wang, Y. Wang, S. Dong, and E. Wang, Polymer, 2006, 47, 763.

    Article  CAS  Google Scholar 

  40. M. Filali, M. A. R. Meier, U. S. Schubert, and J.-F. Gohy, Langmuir, 2005, 21, 7995.

    Article  CAS  PubMed  Google Scholar 

  41. S. Liu, J. V. M. Weaver, M. Save, and S. P. Armes, Langmuir, 2002, 18, 8350.

    Article  CAS  Google Scholar 

  42. N. L. Rosi and C. A. Mirkin, Chem. Rev., 2005, 105, 1547.

    Article  CAS  PubMed  Google Scholar 

  43. C. S. Thaxton, D. G. Georganopoulou, and C. A. Mirkin, Clin. Chim. Acta, 2006, 363, 120.

    Article  CAS  PubMed  Google Scholar 

  44. N. Uehara and T. Nagaoka, “Nanomaterials for the Life Science”, ed. C. S. S. R. Kumer, 2010, Vol. 8, Wiley-VCH, 119.

  45. C. A. Mirkin, R. L. Letsinger, R. C. Mucic, and J. J. Storhoff, Nature, 1996, 382, 607.

    Article  CAS  PubMed  Google Scholar 

  46. M. S. Han, A. K. R. Lytton-Jean, B.-K. Oh, J. Heo, and C. A. Mirkin, Angew. Chem., Int. Ed., 2006, 45, 1807.

    Article  CAS  Google Scholar 

  47. M. S. Han, A. K. R. Lytton-Jean, and C. A. Mirkin, J. Am. Chem. Soc., 2006, 128, 4954.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Y. Liu, Y. Liu, R. L. Mernaugh, and X. Zeng, Biosens. Bioelectron., 2009, 24, 2853.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. C. Wang, Y. Chen, T. Wang, Z. Ma, and Z. Su, Chem. Mater., 2007, 19, 5809.

    Article  CAS  Google Scholar 

  50. K. Aslan, C. C. Luhrs, and V. H. Prez-Luna, J. Phys. Chem. B, 2004, 108, 15631.

    Article  CAS  Google Scholar 

  51. A. Gole and C. J. Murphy, Langmuir, 2005, 21, 10756.

    Article  CAS  PubMed  Google Scholar 

  52. M. Toyoshima and Y. Miura, J. Polym. Sci., Part A, 2009, 47, 1412.

    Article  CAS  Google Scholar 

  53. Y. Sato, T. Murakami, K. Yoshioka, and O. Niwa, Anal. Bioanal. Chem., 2008, 391, 2527.

    Article  CAS  PubMed  Google Scholar 

  54. C. L. Schofield, B. Mukhopadhyay, S. M. Hardy, M. B. McDonnell, R. A. Field, and D. A. Russell, Analyst, 2008, 133, 626.

    Article  CAS  PubMed  Google Scholar 

  55. Y. Zhou, S. Wang, K. Zhang, and X. Jiang, Angew. Chem., Int. Ed., 2008, 47, 7454.

    Article  CAS  Google Scholar 

  56. A. Sugunan, C. Thanachayanont, J. Dutta, and J. G. Hilborn, Sci. Technol. Adv. Mater., 2005, 6, 335.

    Article  CAS  Google Scholar 

  57. S. Kim, J. W. Park, D. Kim, D. Kim, I.-H. Lee, and S. Jon, Angew. Chem., Int. Ed., 2009, 48, 4138.

    Article  CAS  Google Scholar 

  58. S.-Y. Lin, S.-W. Liu, C.-M. Lin, and C.-h. Chen, Anal. Chem., 2002, 74, 330.

    Article  CAS  PubMed  Google Scholar 

  59. Y.-M. Chen, C.-J. Yu, T.-L. Cheng, and W.-L. Tseng, Langmuir, 2008, 24, 3654.

    Article  CAS  PubMed  Google Scholar 

  60. I.-I. S. Lim, D. Mott, W. Ip, P. N. Njoki, Y. Pan, S. Zhou, and C.-J. Zhong, Langmuir, 2008, 24, 8857.

    Article  Google Scholar 

  61. K. Sato, K. Hosokawa, and M. Maeda, J. Am. Chem. Soc., 2003, 125, 8102.

    Article  CAS  PubMed  Google Scholar 

  62. K. Sato, K. Hosokawa, and M. Maeda, Nucleic Acids Res., 2005, 33, e4.

    Article  PubMed  PubMed Central  Google Scholar 

  63. J. Liu and Y. Lu, J. Am. Chem. Soc., 2007, 129, 8634.

    Article  CAS  PubMed  Google Scholar 

  64. Z. Wang, J. H. Lee, and Y. Lu, Adv. Mater., 2008, 20, 3263.

    Article  CAS  Google Scholar 

  65. J. Wang, L. Wang, X. Liu, Z. Liang, S. Song, W. Li, G. Li, and C. Fan, Adv. Mater., 2007, 19, 3943.

    Article  CAS  Google Scholar 

  66. K. A. White and N. L. Rosi, Nanomedicine, 2008, 3, 543.

    Article  CAS  PubMed  Google Scholar 

  67. J.-M. Nam, S. I. Stoeva, and C. A. Mirkin, J. Am. Chem. Soc., 2004, 126, 5932.

    Article  CAS  PubMed  Google Scholar 

  68. J. M. Nam, C. S. Thaxton, and C. A. Mirkin, Science, 2003, 301, 1884.

    Article  CAS  PubMed  Google Scholar 

  69. H. Otsuka, Y. Akiyama, Y. Nagasaki, and K. Kataoka, J. Am. Chem. Soc., 2001, 123, 8226.

    Article  CAS  PubMed  Google Scholar 

  70. S. Takae, Y. Akiyama, H. Otsuka, T. Nakamura, Y. Nagasaki, and K. Kataoka, Biomacromolecules, 2005, 6, 818.

    Article  CAS  PubMed  Google Scholar 

  71. S. Nath, C. Kaittanis, A. Tinkham, and J. M. Perez, Anal. Chem., 2008, 80, 1033.

    Article  CAS  PubMed  Google Scholar 

  72. C. L. Schofield, R. A. Field, and D. A. Russell, Anal. Chem., 2007, 79, 1356.

    Article  CAS  PubMed  Google Scholar 

  73. C. L. Schofield, A. H. Haines, R. A. Field, and D. A. Russell, Langmuir, 2006, 22, 6707.

    Article  CAS  PubMed  Google Scholar 

  74. D. J. Kim, S. M. Kang, B. Kong, W.-J. Kim, H.-J. Paik, H. Choi, and I. S. Choi, Macromol. Chem. Phys., 2005, 206, 1941.

    Article  CAS  Google Scholar 

  75. H. Kobayashi, M. Nishikawa, C. Sakamoto, T. Nishio, H. Kanazawa, and T. Okano, Anal. Sci., 2009, 25, 1043.

    Article  CAS  PubMed  Google Scholar 

  76. T. Shimada, K. Ookubo, N. Komuro, T. Shimizu, and N. Uehara, Langmuir, 2007, 23, 11225.

    Article  CAS  PubMed  Google Scholar 

  77. N. Uehara, K. Ookubo, and T. Shimizu, Langmuir, 2010, 26, 6818.

    Article  CAS  PubMed  Google Scholar 

  78. N. Nerambourg, M. H. V. Werts, M. Charlot, and M. Blanchard-Desce, Langmuir, 2007, 23, 5563.

    Article  CAS  PubMed  Google Scholar 

  79. E. Dulkeith, A. C. Morteani, T. Niedereichholz, T. A. Klar, J. Feldmann, S. A. Levi, F. C. J. M. van Veggel, D. N. Reinhoudt, M. Möller, and D. I. Gittins, Phys. Rev. Lett., 2002, 89, 203002.

    Article  CAS  PubMed  Google Scholar 

  80. S. Tyagi and F. R. Kramer, Nat. Biotechnol., 1996, 14, 303.

    Article  CAS  PubMed  Google Scholar 

  81. G. Goel, A. Kumar, A. K. Puniya, W. Chen, and K. Singh, J. Appl. Microbiol., 2005, 99, 435.

    Article  CAS  PubMed  Google Scholar 

  82. B. Dubertret, M. Calame, and A. J. Libchaber, Nat. Biotechnol., 2001, 19, 365.

    Article  CAS  PubMed  Google Scholar 

  83. N. C. Cady, A. D. Strickland, and C. A. Batt, Mol. Cell. Probes, 2007, 21, 116.

    Article  CAS  PubMed  Google Scholar 

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  1. Department of Applied Chemistry, Graduate School of Engineering, Utsunomiya University, 7-1-2 Yoto, Utsunomiya, Tochigi, 321-8585, Japan

    Nobuo Uehara

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Uehara, N. Polymer-functionalized Gold Nanoparticles as Versatile Sensing Materials. ANAL. SCI. 26, 1219–1228 (2010). https://doi.org/10.2116/analsci.26.1219

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