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Electrochemical Investigation of Interactions between Potential DNA Targeted Compounds, 2,4-Di- and 2,3,4-Trisubstituted Benzimidazo[1,2-a]pyrimidines and Nucleic Acid

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Abstract

The electrochemical aspects of interactions between DNA and two organic compounds are discussed herein. Potential DNA targeted compounds, 2-methyl-4-phenyl-benzo[4,5]imidazo[1,2-a]pyrimidine (c1) and 2,3,4-trimethyl-benzo[4,5]-imidazo[1,2-a]pyrimidine (c2), were synthesized and their cytotoxic and/or growth inhibitory effects were studied previously. Disposable sensor technology was used to explore the interaction between the compounds and nucleic acid, such as fish sperm DNA at the electrode surface and in the solution phase. The changes upon encountering oxidation signals of electroactive DNA base-guanine and these compounds were monitored electrochemically.

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Pharmacy, Ege University, Bornova, Izmir, 35100, Turkey

    Ayfer Caliskan, Hakan Karadeniz & Arzum Erdem

  2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir, 26470, Turkey

    Asiye Meric

Authors
  1. Ayfer Caliskan
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  2. Hakan Karadeniz
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  3. Asiye Meric
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  4. Arzum Erdem
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Correspondence to Arzum Erdem.

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Caliskan, A., Karadeniz, H., Meric, A. et al. Electrochemical Investigation of Interactions between Potential DNA Targeted Compounds, 2,4-Di- and 2,3,4-Trisubstituted Benzimidazo[1,2-a]pyrimidines and Nucleic Acid. ANAL. SCI. 26, 117–120 (2010). https://doi.org/10.2116/analsci.26.117

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