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Preparation of Benzyl Quinine-modified Monolithic Column for Reversed-phase Capillary Electrochromatography

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Abstract

N-Benzylquininium chloride is a versatile functional monomer with quinoline and benzyl groups, which is beneficial for reversed-phase chromatography. In this study, a novel monolithic column with reversed-phase mode was synthesized using N-benzylquininium chloride as the monomer and 3-(acryloyloxy)-2-hydroxypropyl methacrylate as the cross-linker in a binary porogenic solvent consisting of PEG 400 and a 0.05 M sodium hydroxide aqueous solution. The alkaline solution were found to be useful for the improvement of the mechanical stability of the porous monoliths. The monolithic column showed excellent reversed-phase selectivity and various compounds, such as alkylbenzenes, phenols and polycyclic aromatic hydrocarbons, were separated successfully. The highest column efficiency was 1.75 × 105 N m−1. The relative standard deviations of the migration time for thiourea and four alkylbenzenes were all less than 5.0%, which indicates the monolithic column has good stability. The application of the monolithic column for the analysis of polycyclic aromatic hydrocarbons in spiked lake water samples illustrated its great potential for practical application.

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Acknowledgments

This work was supported by the Geological Survey Program of the CGS [grant numbers DD20190573 and DD20189263].

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Authors and Affiliations

  1. Zhengzhou Institute of Multipurpose Utilization of Mineral Resources, CAGS, Zhengzhou, 450006, China

    Xiangju Mao, Xiaofeng Cheng, Zhenfu Lv, Fang Xiao, Lu Liu, Xintao Cheng & Wenshan Ni

  2. China National Engineering Research Center for Utilization of Industrial Minerals, Zhengzhou, 450006, China

    Xiangju Mao, Xiaofeng Cheng, Zhenfu Lv, Fang Xiao, Lu Liu, Xintao Cheng & Wenshan Ni

  3. Key Laboratory of Evaluation and Multipurpose Utilization of Polymetallic Ores, MNR, Zhengzhou, 450006, China

    Xiangju Mao, Xiaofeng Cheng, Zhenfu Lv, Fang Xiao, Lu Liu, Xintao Cheng & Wenshan Ni

  4. Northwest China Center for Geosience Innovation, Xi’an, 710054, China

    Xiangju Mao, Xiaofeng Cheng, Zhenfu Lv, Fang Xiao, Lu Liu, Xintao Cheng & Wenshan Ni

Authors
  1. Xiangju Mao
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  2. Xiaofeng Cheng
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  3. Zhenfu Lv
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  4. Fang Xiao
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  5. Lu Liu
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  6. Xintao Cheng
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  7. Wenshan Ni
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Corresponding author

Correspondence to Wenshan Ni.

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Mao, X., Cheng, X., Lv, Z. et al. Preparation of Benzyl Quinine-modified Monolithic Column for Reversed-phase Capillary Electrochromatography. ANAL. SCI. 37, 261–266 (2021). https://doi.org/10.2116/analsci.20P075

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  • DOI: https://doi.org/10.2116/analsci.20P075

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