Apatite formation abilities of various carrageenan gels in simulated body environment

Ryo NAKATA; Toshiki MIYAZAKI; Yumi MORITA; Eiichi ISHIDA; Ryota IWATSUKI; Chikara OHTSUKI

doi:10.2109/jcersj2.118.487

Feature: Recent Progress in Bioceramics Research: Papers

Apatite formation abilities of various carrageenan gels in simulated body environment

Ryo NAKATA, Toshiki MIYAZAKI, Yumi MORITA, Eiichi ISHIDA, Ryota IWATSUKI, Chikara OHTSUKI

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Keywords: Carrageenan, Apatite, Simulated body fluid (SBF), Organic–inorganic hybrid

JOURNAL FREE ACCESS

2010 Volume 118 Issue 1378 Pages 487-490

DOI https://doi.org/10.2109/jcersj2.118.487

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Abstract

Organic–inorganic hybrids with apatite-forming abilities in physiological environments offer possibilities for building flexible bone-bonding bioactive materials; several functional groups are known to induce apatite nucleation. Here, bioactive organic–inorganic hybrids from κ-carrageenan and λ-carrageenan containing sulfonic groups were prepared. Carrageenan hydrogels were made by cross-linking with CaCl₂. The apatite-forming abilities of each kind of carrageenan hydrogel were examined using simulated body fluid (SBF); λ-carrageenan was found to be superior to κ-carrageenan for this purpose. The former swelled significantly in aqueous conditions, releasing a large amount of Ca²⁺ ions into the SBF, contributing to rapid apatite formation.

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