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Kulkarni, Jo, Kim, and Na: Epi-Leptosphaerin: A New L-Isoascorbic Acid Derivative from Marine Sponges
Original Article

Natural Product Sciences 2015;21(4):293-296.

Published online: 17 January 2015

DOI: https://doi.org/10.20307/nps.2015.21.4.293

Epi-Leptosphaerin: A New L-Isoascorbic Acid Derivative from Marine Sponges

Roshan R. Kulkarni, A Reum Jo, Young Ho Kim, MinKyun Na∗

College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea

∗Author for correspondence Prof. MinKyun Na, College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea Tel: +82-42-821-5925; E-mail: mkna@cnu.ac.kr

      Revised 12 July 201521 September 2015       Accepted 30 September 2015

Copyright © 2015 The Korean Society of Pharmacognosy

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A new L-isoascorbic acid derivative epi-leptosphaerin (1) and two known compounds leptosphaerin (2), and verongamine (3) were isolated from sponges of the orders Verongida and Thorectidae. Compounds 1 and 2 are most likely of sponge-associated fungal origin. In the present study, isolated compounds were investigated for their inhibition of soluble epoxide hydrolase (sEH), which is considered a promising target for the management of pain, inflammation, and comorbidities associated with diabetes. Compound 3, verongamine, displayed weak inhibitory activity against sEH with an IC50 value 51.5 ± 1.0 µM.

Keywords: L-isoascorbic acid, soluble epoxide hydrolase, Verongida sponges

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Fig. 1.
Compounds isolated from the sponges of interest.
nps-21-293f1.tif
Fig. 2.
Key COSY () and HMBC () correlations for compounds 1 and 3.
nps-21-293f2.tif
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