| Development and Utilization of a Mouse Model of Nasal Polyps |
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Sang Wook Kim, Sea Yuong Jeon, Dae Woo Kim |
1Department of Otorhinolaryngology, College of Medicine, Gyeongsang National University, Jinju, Korea. syjeon@nongae.gsnu.ac.kr
2Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju, Korea.
3Department of Otorhinolaryngology-Head and Neck Surgery, Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea. kicubi@daum.net |
| 마우스 비강 폴립 모델의 개발 및 활용 |
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김상욱, 전시영, 김대우 |
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경상대학교 의학전문대학원 이비인후과학교실,1 건강과학연구원,2 서울대학교 의과대학 보라매병원 이비인후과학교실3 |
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| Abstract |
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Systemic corticosteroids currently represent the most effective treatment for chronic rhinosinusitis with nasal polyps (CRSwNP), but their long-term use is constrained due to their detrimental side effects. Until recently, development of novel drugs for CRSwNP has been difficult partly due to the absence of a standard animal model of CRSwNP. Exotoxins of Staphylococcus aureus such as staphylococcal enterotoxin B (SEB), are well-known superantigens which can induce a strong immune response; there have been many studies on the association of staphylococcal enterotoxins and development of CRSwNP over the past two decades. Based on previous studies, we invented a mouse model of CRSwNP using SEB. Herein, we explain the protocol development for the mouse model, as well as identify histological and immunological similarities between this mouse model and humans. Furthermore, we describe a study that analyzed the risk factors for CRSwNP such as smoking, and also elaborate on a series of studies that searched for new potential drugs for CRSwNP, including resveratrol, anti-periostin antibody, topical hypoxia-inducible factors, and topical cyclosporine. Based on preceding studies, we have concluded that this mouse model might be a useful tool to investigate the pathophysiology and development of novel drugs for CRSwNP. |
| Key Words:
Models, animal;Mouse;Nasal polyps;Sinusitis therapeutics |
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