---

Formulation and evaluation of herbal gel for management of mouth ulcers

---

Original Article

Author Details : K. Upadhye*, K Charde, G Dixit, S Bakhle

Volume : 8, Issue : 3, Year : 2021

Article Page : 226-230

https://doi.org/10.18231/j.ijpp.2021.039

Suggest article by email

Get Permission

---

Abstract

Background: Aphthous stomatitis or mouth ulcers is the most common condition that we encounter.
Clinically the lesions are single or multiple superficial and deep sealed and are associated with microbial
invasions.
Aim: This study was conducted with the aim of evaluating the effectiveness of herbal drugs for treatment
of Aphthous stomatitis.
Materials and Methods: In the research work, mouth ulcer gels were formulated incorporating the
ethanolic extracts of as Aloe barbedensis, Ocimum tenuiflorum and Azadirachta indica using carbopol 934
as the gelling agent. Seven batches were formulated by varying the concentration of the herbal ingredients
(F1 to F7)The prepared formulations were evaluated for various parameters like physical appearance, pH,
Spreadability, Homogeneity and antimicrobial activity against fungi and bacteria. The antimicrobial activity
was also compared with a marketed gel formulation.
Results and Discussion: All the prepared formulation using different concentration of plant extract showed
the pH values in between 6.10.2 to 7.00.1. The spreadability values ranged between the 5.0 to 8.0
cm. Out of all the formulations, formulation F7 containing all the three herbal extracts showed a good
spreadability and very promising antimicrobial activity comparable with a marketed gel.
Conclusion: Thus stable, effective gels containing herbal ingredients for management of mouth ulcers can
be developed.

Keywords: Aphthous stomatitis, Aloe barbedensis, Ocimum tenuiflorum, Azadirachta indica, Carbopol 940.

How to cite : Upadhye K, Charde K, Dixit G , Bakhle S, Formulation and evaluation of herbal gel for management of mouth ulcers. Indian J Pharm Pharmacol 2021;8(3):226-230

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.