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Efficacy of dexmedetomidine in attenuating pressor response during general anaesthesia- A randomised controlled trial

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Original Article

Author Details : Prathibha K T, Pooja M N*

Volume : 6, Issue : 3, Year : 2019

Article Page : 401-405

https://doi.org/10.18231/j.ijca.2019.077

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Abstract

Introduction: Dexmedetomidine has shown promising results in obtunding pressor response during direct laryngoscopy and intubation. In this study we have investigated the efficacy of Dexmedetomidine in attenuating pressor response during intubation in terms of variation in mean arterial pressure (MAP), heart rate (HR) in patients undergoing elective surgery under general anaesthesia.
Materials and Methods: Subjects aged 20-50 years requiring general anaesthesia were allocated into group D (with Dexmedetomidine) and group P (without Dexmedetomidine) according to computer generated randomization table. After having met inclusion and exclusion criteria, obtained informed consent, patients were intubated orally with appropriate sized endotracheal tube (ETT) using direct laryngoscopy (DL) and intubation. End points were variation in MAP and HR at 0 minute and 5 minute of DL and intubation. Also other parameters like spo2 and EtCO2 were recorded.
Results: we found that there was highly significant statistical difference between group D and group P.
Conclusion: This comparative study of efficacy of Dexmedetomidine in attenuating pressor response has shown that it is very good premedication for controlling hypertensive episodes during direct laryngoscopy and intubation and thereby decreasing their untoward end organ effects on central nervous system and cardiovascular system.

Keywords: Dexmedetomidine, Direct laryngoscopy, Heart rate, Intubation, Mean arterial pressure, Pressor response.

How to cite : Prathibha K T, Pooja M N, Efficacy of dexmedetomidine in attenuating pressor response during general anaesthesia- A randomised controlled trial. Indian J Clin Anaesth 2019;6(3):401-405

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