Fibroblast growth factors (FGF) – growth factors that regulate many important biological processes, including proliferation and differentiation of embryonic cells during organogenesis. In this review, we will summarize current information about the involvement of FGFs in the pancreas organogenesis. Pancreas organogenesis is a complex process, which involves constant signaling from mesenchymal tissue. This orchestrates the activation of various regulator genes at specific stages, determining the specification of progenitor cells. Alterations in FGF/FGFR signaling pathway during this process lead to incorrect activation of the master genes, which leads to different pathologies during pancreas development. Understanding the full picture about role of FGF factors in pancreas development will make it possible to more accurately understand their role in other pathologies of this organ, including carcinogenesis.
Gnatenko D.A., Kopantzev E.P., Sverdlov E.D. (2017) Fibroblast growth factors and their effects in pancreas organogenesis. Biomeditsinskaya Khimiya, 63(3), 211-218.
Gnatenko D.A. et al. Fibroblast growth factors and their effects in pancreas organogenesis // Biomeditsinskaya Khimiya. - 2017. - V. 63. -N 3. - P. 211-218.
Gnatenko D.A. et al., "Fibroblast growth factors and their effects in pancreas organogenesis." Biomeditsinskaya Khimiya 63.3 (2017): 211-218.
Gnatenko, D. A., Kopantzev, E. P., Sverdlov, E. D. (2017). Fibroblast growth factors and their effects in pancreas organogenesis. Biomeditsinskaya Khimiya, 63(3), 211-218.
Elghazi L., Cras-Méneur C., Czernichow P., Scharfmann R. (2002) Proc. Natl. Acad. Sci. USA, 99(6), 3884-3889. CrossRef Scholar google search
Shirasawa S., Yoshie S., Yokoyama T., Tomotsune D., Yue F., Sasaki K. (2011) Stem Cells Dev., 20(6), 1071-1078. CrossRef Scholar google search
Takizawa-Shirasawa S., Yoshie S., Yue F., Mogi A., Yokoyama T., Tomotsune D., Sasaki K. (2013) Cell Tissue Res., 354(3), 751-759. CrossRef Scholar google search
Uzan B., Figeac F., Portha B., Movassat J. (2009) PLoS One, 4(3), e4734. Scholar google search
Kumar S.S., Alarfaj A.A., Munusamy M.A., Singh A.J., Peng I.C., Priya S.P., Hamat R.A., Higuchi A. (2014) Int. J. Mol. Sci., 15(12), 23418-23447. CrossRef Scholar google search
Delaspre F., Massumi M., Salido M., Soria B., Ravassard P., Savatier P., Skoudy A. (2013) PLoS One, 8(1), e54243. Scholar google search
Pagliuca F.W., Millman J.R., Gürtler M., Segel M., Van Dervort A., Ryu J.H., Peterson Q.P., Greiner D., Melton D.A. (2014) Cell, 159(2), 428-439. CrossRef Scholar google search
Miralles F., Czernichow P., Ozaki K., Itoh N., Scharfmann R. (1999) Proc. Natl. Acad. Sci. USA, 96(11), 6267-6272. CrossRef Scholar google search
Naye F., Voz M.L., Detry N., Hammerschmidt M., Peers B., Manfroid I. (2012) Mol. Biol. Cell, 23(5), 945-954. CrossRef Scholar google search
Arnaud-Dabernat S., Kritzik M., Kayali A.G., Zhang Y.Q., Liu G., Ungles C., Sarvetnick N. (2001) Genes Dev., 15(2), 111-127. CrossRef Scholar google search
Hosokawa S., Furuyama K., Horiguchi M., Aoyama Y., Tsuboi K., Sakikubo M., Goto T., Hirata K., Tanabe W., Nakano Y., Akiyama H., Kageyama R., Uemoto S., Kawaguchi Y. (2015) Sci. Rep., 17(5), 8518. CrossRef Scholar google search
Ahnfelt-Rønne J., Jørgensen M.C., Klinck R., Jensen J.N., Füchtbauer E.M., Deering T., MacDonald R.J., Wright C.V., Madsen O.D., Serup P. (2012) Development, 139(1), 33-45. CrossRef Scholar google search
Rulifson I.C., Karnik S.K., Heiser P.W., ten Berge D., Chen H., Gu X., Taketo M.M., Nusse R., Hebrok M., Kim S.K. (2007) Proc. Natl. Acad. Sci. USA, 104(15), 6247-6252. CrossRef Scholar google search
Berg T., Rountree C.B., Lee L., Estrada J., Sala F.G., Choe A., Veltmaat J.M., De Langhe S., Lee R., Tsukamoto H., Crooks G.M., Bellusci S., Wang K.S. (2007) Hepatology, 46(4), 1187-1197. CrossRef Scholar google search
Itoh N. (2015) Cytokine Growth Factor Rev., S1359-6101(15)30006-X. Scholar google search
