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Alkolün Karaciğer Görünür Difüzyon Katsayısı Değerleri Üzerine Etkileri: Tek Merkez Çalışması

Year 2021, Volume: 20 Issue: 1, 19 - 26, 14.05.2021
https://doi.org/10.17941/agd.927185

Abstract

Giriş ve Amaç: Bu çalışmada aşırı alkol tüketimi öyküsü olan bireyler ve sağlıklı gönüllüler arasında karaciğer diffüzyon ağırlıklı manyetik rezonans görüntüleme ile elde edilen görünür diffüzyon katsayısı değerlerini karşılaştırarak, karaciğer görünür diffüzyon katsayısı değerleri ile potansiyel erken evre karaciğer hasarı arasındaki ilişkiyi araştırmak amaçlanmıştır. Gereç ve Yöntem: Aşırı alkol tüketimi öyküsü olan 35 kişi ve 32 sağlıklı gönüllü bu çalışma için planlanmıştır. Tüm olgularda biyokimyasal parametreleri ölçmek ve tam kan sayımı için kan örnekleri alınmış olup, karaciğer diffüzyon ağırlıklı görüntülemeyi içeren üst abdominal manyetik rezonans görüntüleme yapılmıştır. Bulgular: Aşırı alkol tüketimi öyküsü olan 19 birey ve 20 sağlıklı gönüllü çalışmaya dahil edilmiştir. Aşırı alkol tüketimi öyküsü olan bireylerde yüksek b değeri (b 1000) diffüzyon ağırlıklı görüntülemeyle elde edilen ortalama görünür diffüzyon katsayısı değerleri, sağlıklı gönüllülerden daha düşük bulunmuştur. Her iki grup arasında biyokimyasal parametreler açısından anlamlı bir fark gözlenmese de, her iki gruptaki karaciğer görünür diffüzyon katsayısı değerleri uluslararası normalizasyon oranı değerleri ile pozitif, gama-glutamil transferaz ve alkalen fosfataz değerleri ile negatif korelasyon göstermiştir (sırasıyla r = 0.002, r = -0.007, r = -0.049). Sonuç: Diffüzyon ağırlıklı görüntüleme, alkol tüketiminin neden olduğu karaciğer fibrozisinin saptanması ve takibi için kullanılabilecek noninvaziv bir görüntüleme tekniğidir.

References

  • 1. Federico A, Cotticelli G, Festi D, et al. The effects of alcohol on gastrointestinal tract, liver and pancreas: evidence-based suggestions for clinical management. Eur Rev Med Pharmacol Sci 2015;19:1922-40.
  • 2. Koike N, Cho A, Nasu K, et al. Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions. World J Gastroenterol 2009;15:5805-12.
  • 3. Moteki T, Horikoshi H, Oya N, et al. Evaluation of hepatic lesions and hepatic parenchyma using diffusion-weighted reordered turbo FLASH magnetic resonance images. J Magn Reson Imaging 2002;15:564-72.
  • 4. Ichikawa T, Haradome H, Hachiya J, et al. Diffusion-weighted MR imaging with single-shot echo-planar imaging in the upper abdomen: preliminary clinical experience in 61 patients. Abdom Imaging 1999;24:456-61.
  • 5. Soylu A, Kılıçkesmez Ö, Poturoğlu Ş, et al. Utility of diffusion-weighted MRI for assessing liver fibrosis in patients with chronic active hepatitis. Diagn Interv Radiol 2010;16:204-8.
  • 6. Sandrasegaran K, Akısık FM, Lin C, et al. Value of diffusion-weighted MRI for assessing liver fibrosis and cirrhosis. AJR Am J Roentgenol 2009;193:1556-60.
  • 7. Koinuma M, Ohashi I, Hanafusa K, Shibuya H. Apparent diffusion coefficient measurements with diffusion-weighted magnetic resonance imaging for evaluation of hepatic fibrosis. J Magn Reson Imaging 2005;22:80-5.
  • 8. Bakan AA, Inci E, Bakan S, et al Utility of diffusion weighted imaging in the evaluation of liver fibrosis. Eur Radiol 2012;22:682-7.
  • 9. Lewin M, Poujol-Robert A, Boelle PY, , et al. Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C. Hepatology 2007;46:658-65.
  • 10. Scaglioni F, Ciccia S, Marino M, et al. ASH and NASH. Dig Dis Sci 2011;29:202-10.
  • 11. Basra S, Anand BS. Definition, epidemiology and magnitude of alcoholic hepatitis. World J Hepatol 2011;3:108-13.
  • 12. O'Shea RS, Dasarathy S, McCullough AJ; Practice Guideline Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology. Alcoholic liver disease. Hepatology 2010;51:307-28.
  • 13. Sato N, Lindros KO, Baraona E, et al. Sex difference in alcohol-related organ injury. Alcohol Clin Exp Res 2001;25(5 Suppl ISBRA):40S-45S.
  • 14. Seitz HK, Stickel F. Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biol Chem 2006;387:349-60.
  • 15. Morgan TR, Mandayam S, Jamal MM. Alcohol and hepatocellular carcinoma. Gastroenterology 2004;127:87-96.
  • 16. Ikeda K, Saitoh S, Koida I, et al. A multivariate analysis of risk factor for hepatocellular carcinogenesis: a prospective observation of 795 patients with viral and alcoholic cirrhosis. Hepatology1993;18:47-53.
  • 17. Aube C, Racineux PX, Lebigot J, et al. Diagnosis and quantification of hepatic fibrosis with diffusion weighted MR imaging: preliminary results. J Radiol 2004;85:301-6.
  • 18. Lutsep HL, Albers GW, DeCrespigny A, et al. Clinical utility of diffusion-weighted magnetic resonance imaging in the assessment of ischemic stroke. Ann Neurol 1997;41:574-80.
  • 19. Warach S, Chien D, Li W, et al. Fast magnetic resonance diffusion- weighted imaging of acute human stroke. Neurology 1992;42:1717-23.
  • 20. Muller MF, Prasad P, Siewert B, et al. Abdominal diffusion mapping with use of a whole-body echo-planar system. Radiology 1994;190:475-8.
  • 21. Palmucci S, Mauro LA, Messina M, et al. Diffusion-weighted MRI in a liver protocol: its role in focal lesion detection. World J Radiol 2012;4:302-10.
  • 22. Taouli B, Tolia AJ, Losada M, et al. Diffusion-weighted MRI for quantification of liver fibrosis: preliminary experience. AJR Am J Roentgenol 2007;189:799-806.
  • 23. Colagrande S, Carbone SF, Carusi LM, et al. Magnetic resonance diffusion-weighted imaging: extraneurological applications. Radioln Med 2006;111:392-419.
  • 24. Pasquinelli F, Belli G, Mazzoni LN, et al. MR-diffusion imaging in assessing chronic liver diseases: does a clinical role exist? Radiol Med 2012;117:242-53.
  • 25. Taouli B, Chouli M, Martin AJ, et al. Chronic hepatitis: role of diffusion-weighted imaging and diffusion tensor imaging for the diagnosis of liver fibrosis and inflammation. J Magn Reson Imaging 2008;28:89-95.
  • 26. Asu K, Kuroki Y, Sekiguchi R, et al. Measurement of the apparent diffusion coefficient in the liver: is it a reliable index for hepatic disease diagnosis? Radiat Med 2006;24:438-44.
  • 27. Hsu FO, Chiou YY, Chen CY, et al. Diffusion-weighted magnetic resonance imaging of the liver in hepatitis B patients with Child-Pugh a cirrhosis. Kaohsiung J Med Sci 2007;23:442-6.
  • 28. Tokgöz Ö, Ünal İ, Turgut GG, Yildiz S. The value of liver and spleen ADC measurements in the diagnosis and follow up of hepatic fibrosis in chronic liver disease. Acta Clinica Belgica 2014;69:426-32.
  • 29. Piana G, Trinquart L, Meskine N, et al. New MR imaging criteria with a diffusion-weighted sequence for the diagnosis of hepatocellular carcinoma in chronic liver diseases. J Hepatol 2011;55:126-32.
  • 30. Lewin M, Poujol-Robert A, Boelle PY, et al. Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C. Hepatology 2007;46:658-65.

Effects of Alcohol on Liver Apparent Diffusion Coefficient values: A Single Center Study

Year 2021, Volume: 20 Issue: 1, 19 - 26, 14.05.2021
https://doi.org/10.17941/agd.927185

Abstract

Background and Aims: This study aimed to investigate the relationship between liver apparent diffusion coefficient values and potential early-stage liver injury by comparing apparent diffusion coefficient values obtained by liver diffusion-weighted magnetic resonance imaging between individuals with a history of excessive alcohol consumption and healthy volunteers. Materials and Methods: This study enrolled 35 individuals with a history of excessive alcohol consumption and 32 healthy volunteers. In all cases, blood samples were taken to measure biochemical parameters and complete blood count. Upper abdominal magnetic resonance imaging including liver diffusion-weighted imaging was performed. Results: In total, 19 individuals with a history of excessive alcohol consumption and 20 healthy volunteers were included in the study. The mean apparent diffusion coefficient values obtained by high b value (b 1000) diffusion-weighted imaging in individuals with a history of excessive alcohol consumption were lower than those in healthy volunteers. Although no significant difference was observed between the two groups in terms of biochemical parameters, hepatic apparent diffusion coefficient values in both groups were positively correlated with international normalized ratio values and negatively correlated with gamma-glutamyl transferase and alkaline phosphatase levels (r = 0.002, r = −0.007, r = −0.049, respectively). Conclusion: Diffusion-weighted imaging is a noninvasive imaging technique that can be used for the detection and follow-up of liver fibrosis induced by alcohol consumption.

References

  • 1. Federico A, Cotticelli G, Festi D, et al. The effects of alcohol on gastrointestinal tract, liver and pancreas: evidence-based suggestions for clinical management. Eur Rev Med Pharmacol Sci 2015;19:1922-40.
  • 2. Koike N, Cho A, Nasu K, et al. Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions. World J Gastroenterol 2009;15:5805-12.
  • 3. Moteki T, Horikoshi H, Oya N, et al. Evaluation of hepatic lesions and hepatic parenchyma using diffusion-weighted reordered turbo FLASH magnetic resonance images. J Magn Reson Imaging 2002;15:564-72.
  • 4. Ichikawa T, Haradome H, Hachiya J, et al. Diffusion-weighted MR imaging with single-shot echo-planar imaging in the upper abdomen: preliminary clinical experience in 61 patients. Abdom Imaging 1999;24:456-61.
  • 5. Soylu A, Kılıçkesmez Ö, Poturoğlu Ş, et al. Utility of diffusion-weighted MRI for assessing liver fibrosis in patients with chronic active hepatitis. Diagn Interv Radiol 2010;16:204-8.
  • 6. Sandrasegaran K, Akısık FM, Lin C, et al. Value of diffusion-weighted MRI for assessing liver fibrosis and cirrhosis. AJR Am J Roentgenol 2009;193:1556-60.
  • 7. Koinuma M, Ohashi I, Hanafusa K, Shibuya H. Apparent diffusion coefficient measurements with diffusion-weighted magnetic resonance imaging for evaluation of hepatic fibrosis. J Magn Reson Imaging 2005;22:80-5.
  • 8. Bakan AA, Inci E, Bakan S, et al Utility of diffusion weighted imaging in the evaluation of liver fibrosis. Eur Radiol 2012;22:682-7.
  • 9. Lewin M, Poujol-Robert A, Boelle PY, , et al. Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C. Hepatology 2007;46:658-65.
  • 10. Scaglioni F, Ciccia S, Marino M, et al. ASH and NASH. Dig Dis Sci 2011;29:202-10.
  • 11. Basra S, Anand BS. Definition, epidemiology and magnitude of alcoholic hepatitis. World J Hepatol 2011;3:108-13.
  • 12. O'Shea RS, Dasarathy S, McCullough AJ; Practice Guideline Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology. Alcoholic liver disease. Hepatology 2010;51:307-28.
  • 13. Sato N, Lindros KO, Baraona E, et al. Sex difference in alcohol-related organ injury. Alcohol Clin Exp Res 2001;25(5 Suppl ISBRA):40S-45S.
  • 14. Seitz HK, Stickel F. Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biol Chem 2006;387:349-60.
  • 15. Morgan TR, Mandayam S, Jamal MM. Alcohol and hepatocellular carcinoma. Gastroenterology 2004;127:87-96.
  • 16. Ikeda K, Saitoh S, Koida I, et al. A multivariate analysis of risk factor for hepatocellular carcinogenesis: a prospective observation of 795 patients with viral and alcoholic cirrhosis. Hepatology1993;18:47-53.
  • 17. Aube C, Racineux PX, Lebigot J, et al. Diagnosis and quantification of hepatic fibrosis with diffusion weighted MR imaging: preliminary results. J Radiol 2004;85:301-6.
  • 18. Lutsep HL, Albers GW, DeCrespigny A, et al. Clinical utility of diffusion-weighted magnetic resonance imaging in the assessment of ischemic stroke. Ann Neurol 1997;41:574-80.
  • 19. Warach S, Chien D, Li W, et al. Fast magnetic resonance diffusion- weighted imaging of acute human stroke. Neurology 1992;42:1717-23.
  • 20. Muller MF, Prasad P, Siewert B, et al. Abdominal diffusion mapping with use of a whole-body echo-planar system. Radiology 1994;190:475-8.
  • 21. Palmucci S, Mauro LA, Messina M, et al. Diffusion-weighted MRI in a liver protocol: its role in focal lesion detection. World J Radiol 2012;4:302-10.
  • 22. Taouli B, Tolia AJ, Losada M, et al. Diffusion-weighted MRI for quantification of liver fibrosis: preliminary experience. AJR Am J Roentgenol 2007;189:799-806.
  • 23. Colagrande S, Carbone SF, Carusi LM, et al. Magnetic resonance diffusion-weighted imaging: extraneurological applications. Radioln Med 2006;111:392-419.
  • 24. Pasquinelli F, Belli G, Mazzoni LN, et al. MR-diffusion imaging in assessing chronic liver diseases: does a clinical role exist? Radiol Med 2012;117:242-53.
  • 25. Taouli B, Chouli M, Martin AJ, et al. Chronic hepatitis: role of diffusion-weighted imaging and diffusion tensor imaging for the diagnosis of liver fibrosis and inflammation. J Magn Reson Imaging 2008;28:89-95.
  • 26. Asu K, Kuroki Y, Sekiguchi R, et al. Measurement of the apparent diffusion coefficient in the liver: is it a reliable index for hepatic disease diagnosis? Radiat Med 2006;24:438-44.
  • 27. Hsu FO, Chiou YY, Chen CY, et al. Diffusion-weighted magnetic resonance imaging of the liver in hepatitis B patients with Child-Pugh a cirrhosis. Kaohsiung J Med Sci 2007;23:442-6.
  • 28. Tokgöz Ö, Ünal İ, Turgut GG, Yildiz S. The value of liver and spleen ADC measurements in the diagnosis and follow up of hepatic fibrosis in chronic liver disease. Acta Clinica Belgica 2014;69:426-32.
  • 29. Piana G, Trinquart L, Meskine N, et al. New MR imaging criteria with a diffusion-weighted sequence for the diagnosis of hepatocellular carcinoma in chronic liver diseases. J Hepatol 2011;55:126-32.
  • 30. Lewin M, Poujol-Robert A, Boelle PY, et al. Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C. Hepatology 2007;46:658-65.
There are 30 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

İzzet Ökçesiz This is me 0000-0002-0257-1769

Hakan Artaş This is me 0000-0003-4462-5953

Mehmet Yalnız This is me

Publication Date May 14, 2021
Published in Issue Year 2021 Volume: 20 Issue: 1

Cite

APA Ökçesiz, İ., Artaş, H., & Yalnız, M. (2021). Effects of Alcohol on Liver Apparent Diffusion Coefficient values: A Single Center Study. Akademik Gastroenteroloji Dergisi, 20(1), 19-26. https://doi.org/10.17941/agd.927185

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