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Calcium imaging and dynamic causal modelling reveal brain-wide changes in effective connectivity and synaptic dynamics during epileptic seizures
- Richard E Rosch
- Paul Hunter
- Torsten Baldeweg
- Karl Friston
- Martin Meyer
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Description: For this project, we are investigating network-wide effects of induced seizures in a zebrafish model. We apply dynamic causal modelling to light-sheet microscopy data to identify synaptic dynamics that underlie the observed changes in neuronal output at the level of whole neuronal populations.
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