Open Access, Peer-reviewed
pISSN 2508-8149
eISSN 2508-8459
    Korean J Endocr Surg. 2002 Jun;2(1):15-18. Korean.
    Published online Jun 30, 2002.
    https://doi.org/10.16956/kjes.2002.2.1.15
    Copyright © 2002 Korean Association of Thyroid and Endocrine Surgeons; KATES
    Original Article

    Differentiation of Parathyroid and Thyroid Nodule by Tc-99m Sestamibi Scintigraphy

    Seung Won Seo, M.D.,1 Jae Kyun Joo, M.D.,1 Jung Han Yoon, M.D.,1 Young Jong Jaegal, M.D.,1 and Hee Seung Bom, M.D.2
      • 1Department of Surgery, Chonnam National University Hospital, Gwang-ju, Korea.
      • 2Department of Nuclear Medicine, Chonnam National University Hospital, Gwang-ju, Korea.
    • Correspondence: Email: jhyoon@chonnam.ac.kr
    Accepted June 05, 2002.

    This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Abstract

    Purpose

    Differentiation of parathyroid and thyroid nodule is often difficult even with aids of ultrasonography and computed tomography. Tc-9m sestamibi (MIBI) scintigraphy is useful in the detection of hyperfuntioning parathyroid nodules. However, its role in the differentiation between parathyroid and thyroid nodules including malignancies is not well studied. Therefore, the purpose of this study is to evlauate the role of Tc-99m MIBI imaing in the differentiation of parathyroid adenoma from thyroid malignancy.

    Methods

    Six patients (4 women, 2 men, mean age 43 years) with parathyroid adenoma and 4 patients (2 women, 2 men, mean age 56 years) with thyroid papillary cancer were enrolled. Ten and 180 minutes after injection of 740 MBq Tc-99m MIBI, pinhole image of the anterior neck was obtained. Nodule-to-thyroid ratio (N:T) was measured from same sized region of interests over nodule and normal thyroid bed. Retention Index (RI) was calculated as N:T 10 minus N:T 180 divided by N:T 10.

    Results

    as those with thyroid cancer (1.09 ± 0.35, 1.24 ± 0.36, respectively, P>0.05 ). However, RI of parathyroid patients was higher than thyroid cancer patients (0.64 ± 0.29, -0.12 ± 0.20, respectively, P<0.05).

    Conclusion

    Parathyroid adenoma showed higher retention rate of Tc-99m MIBI than thyroid cancer. Therefore, differntiation of parathyroid and thyroid nodule could be possible using Tc-99m MIBI scintigraphy.

    Keywords
    Tc-99m MIBI; Parathyroid adenoma; Retention index

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