Platelet distribution width as a novel inflammatory marker for fibromyalgia
Öz
Objective:
Fibromyalgia syndrome (FMS) is a benign condition that is characterized by is chronic widespread pain at multiple tender points, systemic
symptoms such as fatigue, cognitive dysfunction and insomnia. The
aim of this study was to investigate the relationship between FMS and platelet
distribution width (PDW), red cell distribution width (RDW), mean platelet
volume (MPV), neutrophil to lymphocyte ratio (NLR), platelets to lymphocyte
ratio (PLR) and other haematological parameters.
Material and
Methods: The
patient group consisted of 200 FMS patients who had met the American
College of Rheumatology (ACR) classification
criteria for FMS, and the control group consisted of 65 healthy volunteers. Carefully
obtained history, detailed physical examination, hematologic and biochemical tests
were performed. The groups were investigated by comparison and correlation
analyzes.
Results: In the FMS
group PDW was 17,1±1,9; RDW was 12,5±1,4; MPV was 8,3±1,2
fl; NLR was 1,81±0,67 and PLR was 114,1±32,4. For the
control group, the results were as; PDW 17,6±2,1;
RDW 12,3±1,2; MPV 8,5±1,4; NLR 1,84±1,11 and PLR 111,9±38,6. There was
no difference between the two groups for RDW, MPV, NLR and PLR. PDW was
statistically significantly lower in FMS group than controls (p <0.05).
Conclusions: PDW may
play a role as an early inflammatory marker for the pathogenesis and diagnosis
of FMS.
Anahtar Kelimeler
Fibromyalgia syndrome FMS haematological parameters platelet distribution width PDW
Kaynakça
- Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014 Apr 16;311(15):1547-55.
- Talotta R, Bazzichi L, Di Franco M, Casale R, Batticciotto A, Gerardi MC, et al. One year in review 2017: fibromyalgia. Clin Exp Rheumatol. 2017 May-Jun;35 Suppl 105(3):6-12.
- Russell IJ, Larson AA. Neurophysiopathogenesis of fibromyalgia syndrome: a unified hypothesis. Rheum Dis Clin North Am. 2009 May;35(2):421-35.
- Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007; 357:2482–2494.
- Sansanayudh N, Numthavaj P, Muntham D, Yamwong S, McEvoy M, Attia J, et al. Prognostic effect of mean platelet volume in patients with coronary artery disease. A systematic review and meta-analysis. Thromb Haemost. 2015 Nov 25;114(6):1299-1309.
- Chia S, Nagurney JT, Brown DF, Raffel OC, Bamberg F, Senatore F, et al. Association of leukocyte and neutrophil counts with infarct size, left ventricular function and outcomes after percutaneous coronary intervention for ST-elevation myocardial infarction. Am J Cardiol 2009; 103(3):333–337.
- Bian C, Wu Y, Shi Y, Xu G, Wang J, Xiang M, et al. Predective value of the relative lymphocyte count in coronary heart disease. Heart Vessels 2010; 25(6):469–473.
- Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010 Jan;14(1):28-32.
- Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American college of rheumatology 1990 criteria for the classification of fibromyalgia. Arthritis Rheum. 1990 Feb;33(2):160-72.
- Xiao Y, Haynes WL, Michalek JE, Russell IJ. Elevated serum high-sensitivity C-reactive protein levels in fibromyalgia syndrome patients correlate with body mass index, interleukin-6, interleukin-8, erythrocyte sedimentation rate. Rheumatol Int. 2013 May;33(5):1259-64.
- Rodriguez-Pintó I, Agmon-Levin N, Howard A, Shoenfeld Y. Fibromyalgia and cytokines. Immunol Lett. 2014 Oct;161(2):200-3
- Işık M, Şahin H, Hüseyin E. New platelet indices as inflammatory parameters for patients with rheumatoid arthritis. Eur J Rheumatol. 2014 Dec;1(4):144-146.
- Yazici S, Yazici M, Erer B, Erer B, Calik Y, Ozhan H, et al. The platelet indices in patients with rheumatoid arthritis:mean platelet volume reflects disease activity. Platelets. 2010;21(2):122-5.
- Haliloğlu S, Carlioglu A, Sahiner E, Karaaslan Y, Kosar A. Mean platelet volume in patients with fibromyalgia. Z Rheumatol. 2014 Oct;73(8):742-5.
- Montagnana M, Cervellin G, Meschi T, Lippi G. The role of red blood cell distribution width in cardiovascular and thrombotic disorders. Clin Chem Lab Med. 2011 Dec 17;50(4):635-641.
- Al-Nimer MSM, Mohammad TAM, Alsakeni RA. Serum levels of serotonin as a biomarker of newly diagnosed fibromyalgia in women: Its relation to the platelet indices. J Res Med Sci. 2018 Aug 23;23:71.
- Aktürk S, Büyükavcı R. Evaluation of blood neutrophil-lymphocyte ratio and platelet distribution width as inflammatory markers in patients with fibromyalgia. Clin Rheumatol. 2017 Aug;36(8):1885-1889.
- Al-Nimer MSM, Mohammad TAM. Correlation of hematological indices and ratios derived from them with FIQR scores in fibromyalgia. Pak J Med Sci. 2018 Sep-Oct;34(5):1219-1224.
- Ataoglu S, Ankarali H, Samanci R, Ozsahin M, Admis O. The relationship between serum leptin level and disease activity and inflammatory markers in fibromyalgia patients. North Clin Istanb. 2018 Apr 16;5(2):102-108.
Fibromiyalji tanısında inflamatuar bir belirteç: Platelet dağılım genişliği
Öz
Amaç: Fibromiyalji sendromu (FMS), çoklu
hassas noktalarda kronik yaygın ağrı ile karakterize, yorgunluk, uykusuzluk,
kognitif disfonksiyonlarda bozukluk vb. sistemik semptomlarla bir arada
seyreden bir sendromdur. Bu çalışmanın amacı, FMS tanılı
hastalar ile kontrol grubu arasındaki platelet dağılım genişliği (PDW), kırmızı
küre dağılım genişliği (RDW), ortalama trombosit hacmi (MPV), nötrofil/lenfosit
oranı (NLR), platelet/lenfosit oranı (PLR) hematolojik parametrelerini
araştırmak ve hastalık etyopatogenezine katkı sağlamaktır.
Gereç ve Yöntem: Fizik
Tedavi ve Rehabilitasyon polikliniğine ayaktan başvuran ve ‘American College of Rheumatology’ (ACR) kriterlerine göre FMS tanısı
konan 200 hasta ve 65 sağlıklı birey çalışmaya dahil edildi. Muayeneleri
kapsamında ayrıntılı anamnez alımı, detaylı fizik muayene, hematolojik ve
biyokimyasal parametreleri incelendi. İstatistiksel olarak karşılaştırma ve
analizleri yapıldı.
Bulgular: FMS
grubunda PDW 17,1±1,9, RDW 12,5±1,4; MPV 8,3±1,2
fentolitre (fl); NLR 1,81±0,67; PLR 114,1±32,4
idi. Kontrol grubunun ise PDW değeri 17,6±2,1 (p=0,034);
RDW 12,3±1,2; MPV 8,5±1,4; NLR 1,84±1,11; PLR 111,9±38,6 idi. Yapılan
karşılaştırmalarda RDW, MPV, NLR, PLR de her iki grup arasında fark
saptanmazken; FMS tanılı hastalarda PDW, kontrol grubuna göre istatistiksel
olarak anlamlı düzeyde düşük saptandı (p<0.05).
Sonuç: PDW’nin, FMS patogenezinde muhtemel inflamatuar aktivitenin hematolojik
parametrelerdeki göstergesi olarak ve FMS nin erken tanısında bir belirteç
olarak rolü olabilir.
Anahtar Kelimeler
Fibromiyalji sendromu FMS hematolojik parametreler platelet dağılım genişliği PDW
Kaynakça
- Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014 Apr 16;311(15):1547-55.
- Talotta R, Bazzichi L, Di Franco M, Casale R, Batticciotto A, Gerardi MC, et al. One year in review 2017: fibromyalgia. Clin Exp Rheumatol. 2017 May-Jun;35 Suppl 105(3):6-12.
- Russell IJ, Larson AA. Neurophysiopathogenesis of fibromyalgia syndrome: a unified hypothesis. Rheum Dis Clin North Am. 2009 May;35(2):421-35.
- Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007; 357:2482–2494.
- Sansanayudh N, Numthavaj P, Muntham D, Yamwong S, McEvoy M, Attia J, et al. Prognostic effect of mean platelet volume in patients with coronary artery disease. A systematic review and meta-analysis. Thromb Haemost. 2015 Nov 25;114(6):1299-1309.
- Chia S, Nagurney JT, Brown DF, Raffel OC, Bamberg F, Senatore F, et al. Association of leukocyte and neutrophil counts with infarct size, left ventricular function and outcomes after percutaneous coronary intervention for ST-elevation myocardial infarction. Am J Cardiol 2009; 103(3):333–337.
- Bian C, Wu Y, Shi Y, Xu G, Wang J, Xiang M, et al. Predective value of the relative lymphocyte count in coronary heart disease. Heart Vessels 2010; 25(6):469–473.
- Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010 Jan;14(1):28-32.
- Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American college of rheumatology 1990 criteria for the classification of fibromyalgia. Arthritis Rheum. 1990 Feb;33(2):160-72.
- Xiao Y, Haynes WL, Michalek JE, Russell IJ. Elevated serum high-sensitivity C-reactive protein levels in fibromyalgia syndrome patients correlate with body mass index, interleukin-6, interleukin-8, erythrocyte sedimentation rate. Rheumatol Int. 2013 May;33(5):1259-64.
- Rodriguez-Pintó I, Agmon-Levin N, Howard A, Shoenfeld Y. Fibromyalgia and cytokines. Immunol Lett. 2014 Oct;161(2):200-3
- Işık M, Şahin H, Hüseyin E. New platelet indices as inflammatory parameters for patients with rheumatoid arthritis. Eur J Rheumatol. 2014 Dec;1(4):144-146.
- Yazici S, Yazici M, Erer B, Erer B, Calik Y, Ozhan H, et al. The platelet indices in patients with rheumatoid arthritis:mean platelet volume reflects disease activity. Platelets. 2010;21(2):122-5.
- Haliloğlu S, Carlioglu A, Sahiner E, Karaaslan Y, Kosar A. Mean platelet volume in patients with fibromyalgia. Z Rheumatol. 2014 Oct;73(8):742-5.
- Montagnana M, Cervellin G, Meschi T, Lippi G. The role of red blood cell distribution width in cardiovascular and thrombotic disorders. Clin Chem Lab Med. 2011 Dec 17;50(4):635-641.
- Al-Nimer MSM, Mohammad TAM, Alsakeni RA. Serum levels of serotonin as a biomarker of newly diagnosed fibromyalgia in women: Its relation to the platelet indices. J Res Med Sci. 2018 Aug 23;23:71.
- Aktürk S, Büyükavcı R. Evaluation of blood neutrophil-lymphocyte ratio and platelet distribution width as inflammatory markers in patients with fibromyalgia. Clin Rheumatol. 2017 Aug;36(8):1885-1889.
- Al-Nimer MSM, Mohammad TAM. Correlation of hematological indices and ratios derived from them with FIQR scores in fibromyalgia. Pak J Med Sci. 2018 Sep-Oct;34(5):1219-1224.
- Ataoglu S, Ankarali H, Samanci R, Ozsahin M, Admis O. The relationship between serum leptin level and disease activity and inflammatory markers in fibromyalgia patients. North Clin Istanb. 2018 Apr 16;5(2):102-108.