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European Journal of Dermatology

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Changes in serum desnutrin levels in patients with acne vulgaris Volume 24, numéro 5, September-October 2014

Illustrations


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Tableaux

Auteurs
1 Department of Dermatology,
Firat University Hospital,
Elazig, Turkey
2 Department of Dermatology,
Dicle University Hospital,
Diyarbakir, Turkey
3 Department of Biochemistry and Clinical Biochemistry,
Firat University Hospital,
Elazig, Turkey
4 Clinic of Dermatology,
Elazig Education and Research Hospital,
Elazig, Turkey
* Reprints

Background: Androgens and insulin may contribute to increased sebum production in the pathogenesis of acne vulgaris. Objective:We investigated the association between serum desnutrin levels and acne vulgarisin the pathogenesis of insulin resistance.Material and methods: 25 patients presenting with acne vulgaris and 25 control subjects participated in this study. Fasting blood glucose, triglycerides, LDL, VLDL, HDL, total cholesterol, insulin, C-peptide and thyroid function tests were measured. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate insulin resistance. Desnutrin levels were determined by enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's protocol.Results: Patients with acne vulgaris had a mean serum desnutrin level of (8.83 ± 1.13 μIU/mL), which was statistically significantly lower in the control group (10:58 ± 3.43 μIU/mL). In patients with acne vulgaris the serum glucose levels, insulin levels and HOMA-IR values (87.92 ± 7:46 mg/dL, 11.33 ± 5.93 μIU/mL, 2.49 ± 1.40, respectively) were significantly higher than the control group (77.36 ± 9.83 mg/dL, 5.82 ± 2.68 μIU/mL, 1.11 ± 0.51, respectively) (p = 0.01, p<0.001, p<0.001, p<0.001, respectively). Conclusion: Full cohort (patients and controls) evaluation revealed a negative correlation between the serum glucose and desnutrin levels (r = -0.31, p<0.05). A positive correlation was found between insulin and desnutrin levels (r = 0.42, p<0.001). In patients with acne vulgaris, as a result of increased levels of serum glucose and insulin, the function of desnutrin was suppressed, perhaps contributing to insulin resistance.