Abstract
In our study, 50 patients with dilated cardiomyopathy (DCM) were selected to investigate the correlation between virus persistent infection and cardic function. We found that 44% of patients with DCM were coxsackie virus B-RNA (CVB-RNA) positive, significantly different from that (20%) of the normal control group (P<0.05). The expression levels of coxsackie adenovirus receptor (CAR) in patients with DCM were significantly higher than those in the normal control group (P<0.01). In CVB-RNA-positive patients, expression levels of CAR were significantly higher than those in CVB-RNA-negative patients (P<0.01). There was a positive correlation between CAR expression and brain natriuretic peptide (BNP) level in patients with DCM, but no significant correlations between the CAR expression level and left ventricular ejection fraction (LVEF) or left ventricular end diastolic diameter (LVEDd). These results showed that expression levels of CAR on the surface of white cells can be used as an indicator for detecting persistent virus infection. We found that expression levels of CAR and heart function in patients with DCM were highly correlated.
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References
Chen, S.X., Xie, L.S., Mei, S.W., Qian, F.R., Chen, M.F., 2003. The significance of coxsackie virus B RNA and antibody detection in the diagnosis of viral myocarditis. Chin. J. Lab. Med., 26(3):166–168 (in Chinese).
Feuer, R., Mena, I., Pagarigan, R., Slifka, M.K., Whitton, J.L., 2002. Cell cycle status affects coxsackievirus replication, persistence and reaction in vitro. J. Vurol., 76(9):4430–4440. [doi:10.1128/JVI.76.9.4430-4440.2002]
Fujioka, S., Kitaura, Y., Terasaki, F., 2008. Etiology and quantitative evaluation of viral infection in the myocardium of patients with end-stage idiopathic dilated cardiomyopathy. J. Mol. Cell. Cardiol., 45(4):S33. [doi:10.1016/j.yjmcc.2008.09.700]
Jane-wit, D., Altuntas, C.Z., Johnson, J.M., Yong, S., Wickley, P.J., Clark, P., Wang, Q., Popović, Z.B., Penn, M.S., Damron, D.S., et al., 2007. β1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis. Circulation, 116(4):399–410. [doi:10.1161/CIRCULATIONAHA.106.683193]
Leuschner, F., Katus, H.A., Kaya, Z., 2009. Autoimmune myocarditis: past, present and future. J. Autoimm., 33(3–4):282–289. [doi:10.1016/j.jaut.2009.07.009]
Liao, Y.H., Yang, Y.Z., Wang, C.H., 2007. Dilated cardiomyopathy. Chin. J. Cardiovasc. Dis., 35(1):5–9 (in Chinese).
Ling, W., Shen, Q., Wang, J., Xu, Y.L., Xu, Y., 2001. Experimental study of the immuno-PCR assay coxsackie virus group B antigen. J. Sec. Milit. Med. Univ., 22(3): 264–266 (in Chinese).
Liu, P.P., Mason, J.W., 2001. Advances in the understanding of myocarditis. Circulation, 104(9):1076–1082. [doi:10. 1161/hc3401.095198]
McCullough, P.A., Omland, T., Maisel, A.S., 2003. B-type natriuretic peptides: a diagnostic breakthrough for clinicians. Rev. Cardiovasc. Med., 4(2):72–80.
Nishtala, K., Phong, T.Q., Steil, L., Sauter, M., Salazar, M.G., Kandolf, R., Kroemer, H.K., Felix, S.B., Völker, U., Klingel, K., et al., 2011. Virus-induced dilated cardiomyopathy is characterized by increased levels of fibrotic extracellular matrix proteins and reduced amounts of energy-producing enzymes. Proteomics, 11(22):4310–4320. [doi:10.1002/pmic.201100229]
Ye, C.H., Chen, Z.Q., 2009. Experimental study on granzyme B expression in mouse with viral myocarditis. Chin. J. Microbiol. Immunol., 29(11):1019–1024 (in Chinese).
Yu, X.H., Li, S.J., Tang, G.H., 2005. Expression and significance of coxsackie adenovirus receptor in peripheral white blood cell of children with viral myocarditis. J. Clin. Pediatr., 23(7):470–472 (in Chinese).
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Project (No. 2007CB144) supported by the Traditional Chinese Medicine (TCM) Project of Zhejiang Province, China
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Liu, Q., Su, Xj., Yu, Y. et al. Correlation between virus persistent infection and cardic function in patients with dilated cardiomyopathy. J. Zhejiang Univ. Sci. B 14, 749–753 (2013). https://doi.org/10.1631/jzus.BQICC708
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DOI: https://doi.org/10.1631/jzus.BQICC708