Abstract
With the development of modern sequencing techniques and bioinformatics, genomes that were once thought to be noncoding have been found to encode abundant functional micropeptides (miPs), a kind of small polypeptides. Although miPs are difficult to analyze and identify, a number of studies have begun to focus on them. More and more miPs have been revealed as essential for energy metabolism homeostasis, immune regulation, and tumor growth and development. Many reports have shown that miPs are especially essential for regulating glucose and lipid metabolism and regulating mitochondrial function. MiPs are also involved in the progression of related diseases. This paper reviews the sources and identification of miPs, as well as the functional significance of miPs for metabolism-related diseases, with the aim of revealing their potential clinical applications.
摘要
随着现代测序和生物信息学技术的进展,曾被认为不具有编码功能的基因组已被证实能编码功能性小多肽——微肽(miPs)。尽管miPs的鉴定和分析仍较困难,但miPs已进入了许多研究者的视野。越来越多的miPs被发现在能量代谢、免疫调节和肿瘤生长发育中发挥重要作用。有研究表明,在代谢相关疾病中,miPs可调节糖脂代谢和线粒体功能。本文对miPs来源、鉴定及在代谢相关疾病中的作用和意义进行综述,以期揭示其潜在的临床价值。
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This work was supported by the National Natural Science Foundation of China (No. 81870237). All the figures were created with Biorender.com.
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Yirui LU and Yutong RAN were responsible for writing – original draft. Hong LI and Jiao WEN were responsible for supervision. Xiaodong CUI and Xiaoyun ZHANG were responsible for conceptualization. Xiumei GUAN was responsible for writing – review & editing. Min CHENG was responsible for supervision, writing – review & editing, and funding acquisition. All authors have read and approved the final manuscript.
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Yirui LU, Yutong RAN, Hong LI, Jiao WEN, Xiaodong CUI, Xiaoyun ZHANG, Xiumei GUAN, and Min CHENG declare that they have no conflict of interest.
This article does not contain any studies with human or animal subjects performed by any of the authors.
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Lu, Y., Ran, Y., Li, H. et al. Micropeptides: origins, identification, and potential role in metabolism-related diseases. J. Zhejiang Univ. Sci. B 24, 1106–1122 (2023). https://doi.org/10.1631/jzus.B2300128
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DOI: https://doi.org/10.1631/jzus.B2300128