Abstract
The present study aimed to evaluate the anti-diabetic property of peanut shell polyphenol extracts (PSPEs). Diabetic rats were oral-administrated with PSPE at doses of 50, 100, and 200 mg/kg body weight (BW) per day for 28 consecutive days, with metformin (Met) as a positive control. The results showed that, similar to the Met treatment, administration of PSPE caused significant decreases in food intake, water intake, fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, and methane dicarboxylic aldehyde in serum, and significant increases in BW, insulin level, high-density lipoprotein cholesterol, superoxide dismutase, glutathione, and liver glycogen. Further, glucose tolerance was markedly improved in the PSPE-treated diabetic groups. Histopathological results showed that PSPE improved cellular structural and pathological changes in liver, kidney, and pancreatic islets. Collectively, the results indicated that the hypoglycemic effects of PSPE on high-fat diet/streptozotocin (HFD/STZ)- induced diabetes are comparable to Met, though their exact mechanism actions are still under investigation. Therefore, the current study suggests that PSPE could be a potential health-care food supplement in the management of diabetes.
中文概要
目的
评估花生壳多酚提取物的抗糖尿病活性。
创新点
明确了花生壳多酚的抗糖尿病活性。
方法
通过高脂饮食/链脲霉素(HFD/STZ)诱导产生糖尿病小鼠。将糖尿病小鼠随机分为四组:二甲双胍组、花生壳多酚高、中、低剂量组(分别为200、 100 和50 mg/kg);同时设置正常对照组及糖尿 病对照组。二甲双胍及花生壳多酚每日口服一 次,剂量为每天10 ml/kg 体重,持续4周;考察不同剂量的花生壳多酚对糖尿病小鼠的体重、饮食、饮水,空腹血糖、血清总胆固醇、血脂、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇,及血 液中超氧化物歧化酶、谷胱甘肽、丙二醛、肝糖 原水平的影响;并对小鼠的肝脏、肾脏和胰岛组 织进行组织学分析。
结论
花生壳多酚具有一定的降血糖作用,可作为潜在 的食物补充剂应用于糖尿病患者的饮食管理中。
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Project supported by the China Scholarship Council (No. 201306175110) and the Major Scientific and Technological Research Project of Jilin Province (No. 20140204048NY), China
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Sun, Xm., Ye, Hq., Liu, Jb. et al. Assessment of anti-diabetic activity of peanut shell polyphenol extracts. J. Zhejiang Univ. Sci. B 19, 764–775 (2018). https://doi.org/10.1631/jzus.B1700401
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DOI: https://doi.org/10.1631/jzus.B1700401