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Advances in researches on the immune dysregulation and therapy of severe acute pancreatitis

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Abstract

During the development and progression of severe acute pancreatitis (SAP), conspicuous immune dysregulation develops, which is mainly manifested as excessive immune response in the early stage and immunosuppression in the late stage. This process involves complex changes in a variety of immune molecules and cells, such as cytokines, complements, lymphocytes, and leukocytes. With the gradual deepening of studies on the development and progression of SAP, the role of immune dysregulation in the pathogenesis of SAP has attracted more and more attention. In this article, we review the advances in research on the immune dysregulation in SAP and the immunotherapy of this disease through exploring the formation of excessive immune response and immune suppression as well as their mutual transformation.

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Authors and Affiliations

  1. Department of General Surgery, Hangzhou First People’s Hospital, Hangzhou, 310006, China

    Xi-ping Zhang

  2. The First College of Clinical Medicine, Zhejiang University of Traditional Chinese Medicine, Hangzhou, 310053, China

    Han-qing Chen & Jie Zhang

  3. Department of Acupuncture and Moxibustion, Hangzhou Hospital of Red Cross Society, Hangzhou, 310003, China

    Fang Liu

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  1. Xi-ping Zhang
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  2. Han-qing Chen
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  3. Fang Liu
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  4. Jie Zhang
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Correspondence to Xi-ping Zhang.

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Project supported by the Technological Foundation Project of Traditional Chinese Medicine Science of Zhejiang Province (Nos. 2003C130 and 2004C142), and the Foundation Project for Medical Science and Technology of the Health Bureau of Zhejiang Province (No. 2003B134), China

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Zhang, Xp., Chen, Hq., Liu, F. et al. Advances in researches on the immune dysregulation and therapy of severe acute pancreatitis. J. Zhejiang Univ. Sci. B 10, 493–498 (2009). https://doi.org/10.1631/jzus.B0820265

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  • DOI: https://doi.org/10.1631/jzus.B0820265

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