Abstract
This report gives a better emphasis on the role of targeted effectors (e.g. a combination of 5-FC with CD-NSPCs as compared to the application of NSPCs alone) and how such delivery of pro-drug activating enzymes and other tumor-killing substances may overcome melanocytic defence system, interact with and promote the host defence and immune response modulations not only in melanoma but, potentially, in other highly-metastatic cancers.
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References
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An earlier development of these novel theoretical conjectures may be traced back to one of authors’ original peer-reviewed works that was accepted for publication just within 9 days from receipt by the Medical Hypotheses (Dimitrov, 1993) as well as to the second one in the European Journal of Dermatology (Dimitrov, 1997) with the critical comments by Prof. Patrick A. Riley from UCLMS (England). The most recent description of Melanocytic Defence System (MDS) research and development was presented in part at the 10th PASPCR Annual Meeting in Minneapolis (USA) by Dimitrov and Rachkova (2001) (http://dx.doi.org/10.1034/j.1600-0749.2001.140313.x). Detailed references for each of the above assumptions are presented within the authors’ poster at this meeting; both are available upon written request to the authors at pp_atanassova@yahoo.com or bdd11@yahoo.com. The biochemically-based 4-step tyrosinase model of “host-matched interaction” for melanoma metastases by Rachkova and Dimitrov (1999) represented one of the most important works on which the 2003 US Patent No. 7030129 is based (Miller et al., 2003; available from the authors as well as upon free registration at http://www.freepatentsonline.com/7030129.html).
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Dimitrov, B.D., Atanassova, P.A. & Rachkova, M.I. Brain metastases of melanoma—mechanisms of attack on their defence system by engineered stem cells in the microenvironment. J. Zhejiang Univ. - Sci. B 8, 609–611 (2007). https://doi.org/10.1631/jzus.2007.B0609
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DOI: https://doi.org/10.1631/jzus.2007.B0609