Abstract
Objective
To evaluate the effect of preimplantation genetic diagnosis (PGD) conducted for women who had Down syndrome pregnancy previously.
Methods
Trisomy 21 was diagnosed by using fluorescence in site hybridization (FISH) before embryo transfer in two women who had Down syndrome pregnancies. Each received one or two PGD cycles respectively.
Results
Case 1: one PGD cycle was conducted, two oocytes were fertilized and biopsied. One embryo is of trisomy 21 and the other of monosomy 21. No embryo was transferred. Case 2: two PGD cycles were conducted, in total, sixteen oocytes were fertilized and biopsied. Four embryos were tested to be normal, six of trisomy 21, and one of monosomy 21. Five had no signal. Four normal embryos were transferred but no pregnancy resulted.
Conclusion
For couples who had pregnancies with Down syndrome previously, PGD can be considered, and has been shown to be an effective strategy.
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Project supported by the National Basic Research Program of China (Nos. 2006CB944006 and 2006CB504004), the Key Research Program of Zhejiang Province, China (No. 2006C13078) and the Bureau of Science and Technology of Hangzhou, China (No. 20061123B03)
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Zhang, Y., Xu, Cm., Zhu, Ym. et al. Preimplantation genetic diagnosis for Down syndrome pregnancy. J. Zhejiang Univ. - Sci. B 8, 515–521 (2007). https://doi.org/10.1631/jzus.2007.B0515
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DOI: https://doi.org/10.1631/jzus.2007.B0515