The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Regular Contributions
A Comparison of Amino Acid Sequences of Hepatitis B Virus S Gene in 46 Children Presenting Various Clinical Features for Immunoprophylaxis
Yoshishige Miyake, Takaya Oda, Rou Li, Kohachiro Sugiyama
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Keywords: hepatitis B virus, mother-to-child transmission, antibody escape mutant, S gene
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1996 Volume 180 Issue 3 Pages 233-247

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Abstract

We compared amino acid sequences of hepatitis B virus (HBV) S protein deduced from analyzed DNA sequence in 46 children who received immunoprophylaxis to prevent mother-to-child transmission of HBV. They were classified into 6 groups by their clinical features. The antibody escape mutants were found in 8 cases among 46 cases. We studied the difference in clinical features in these cases and speculated that 126 Ser or 140 Ser-strain may have a different behavior in relation to antibody to hepatitis B surface antigen from 126 Asn or 145 Arg-strain.

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© 1996 Tohoku University Medical Press
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