Abstract
The aqueous extract (AE) and isolated fraction (ppt-3) of Cuphea carthagenensis (Jacq.) J. F. Macbr (sete-sangrias) were tested using models of nociception and inflammation in mice. Oral administration (p.o.) of the AE (10 to 100 mg/kg) and fraction ppt-3 (0.1 to 10 mg/kg) reduced the acetic acid-induced writhing in mice by 40 to 50% and by 46 to 70% of control, respectively. At the same doses AE and ppt-3 did not affect the tail flick response. Fraction ppt-3 also reduced the carrageenininduced paw edema, but at a dose 1000 times higher than that inducing antinociception. The results indicated the presence in the plant of antinociceptive constituents devoid of antiinflammatory activity, with actions apparently mediated by non-opioid mechanisms.
Antinociceptive and antiinflammatory activities of the aqueous extract and isolated Cuphea carthagenensis (Jacq.) J. F. Macbr.
Francis Rigolo FernandesI; André Luis dos SantosI; Ana Maria Soares de ArrudaII; Luciana de Miranda C. Vasques-PintoI; Rosely Oliveira GodinhoI; Luce Maria Brandão TorresI; Antonio José LapaI; Caden SouccarI, * * csouccar.farm@infar.epm.br
IDepartment of Pharmacology, Natural Products Section, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Três de Maio 100, 04044-020, São Paulo, SP
IIDepartment of Pharmacology, Universidade Federal do Paraná, Curitiba, PR, Brazil
ABSTRACT
The aqueous extract (AE) and isolated fraction (ppt-3) of Cuphea carthagenensis (Jacq.) J. F. Macbr (sete-sangrias) were tested using models of nociception and inflammation in mice. Oral administration (p.o.) of the AE (10 to 100 mg/kg) and fraction ppt-3 (0.1 to 10 mg/kg) reduced the acetic acid-induced writhing in mice by 40 to 50% and by 46 to 70% of control, respectively. At the same doses AE and ppt-3 did not affect the tail flick response. Fraction ppt-3 also reduced the carrageenininduced paw edema, but at a dose 1000 times higher than that inducing antinociception. The results indicated the presence in the plant of antinociceptive constituents devoid of antiinflammatory activity, with actions apparently mediated by non-opioid mechanisms.
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Acknowledgments
This work was supported by grants from Central de Medicamentos (CEME - MS) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). FRF was a recipient of a fellowship from CNPq (IC); ALS and LMCVP received a MS fellowship from CAPES.
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Publication Dates
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Publication in this collection
05 Oct 2009 -
Date of issue
2002
