Strigolactones—a novel class of phytohormones as anti-cancer agents

Mohammed Nihal Hasan; Syed S. I. Razvi; Abudukadeer Kuerban; Khadijah Saeed Balamash; Widad M. Al-Bishri; Khalid Omar Abulnaja; Hani Choudhry; Jehan A. Khan; Said Salama Moselhy; Zamzami Ma; Taha A. Kumosani; Abdulrahman L. Al-Malki; Mahmoud Alhosin; Tadao Asami

doi:10.1584/jpestics.D17-090

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Strigolactones—a novel class of phytohormones as anti-cancer agents

Mohammed Nihal Hasan, Syed S. I. Razvi, Abudukadeer Kuerban, Khadijah Saeed Balamash, Widad M. Al-Bishri, Khalid Omar Abulnaja, Hani Choudhry, Jehan A. Khan, Said Salama Moselhy , Zamzami Ma, Taha A. Kumosani, Abdulrahman L. Al-Malki, Mahmoud Alhosin, Tadao Asami

Author information

Mohammed Nihal Hasan
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Syed S. I. Razvi
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Abudukadeer Kuerban
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Khadijah Saeed Balamash
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Widad M. Al-Bishri
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Khalid Omar Abulnaja
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Experimental Biochemistry Unit, King Fahd Medical Research Center
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Bioactive Natural Products Research Group
Hani Choudhry
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Medical Research Center
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Bioactive Natural Products Research Group
Jehan A. Khan
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Biological Sciences Department (Genomic division), Faculty of Science
Said Salama Moselhy Corresponding author
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Experimental Biochemistry Unit, King Fahd Medical Research Center
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Bioactive Natural Products Research Group
Department of Biochemistry, Faculty of Science, Ain Shams University
Zamzami Ma
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Medical Research Center
Taha A. Kumosani
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Experimental Biochemistry Unit, King Fahd Medical Research Center
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Production of Bioproducts for Industrial Applications Research Group
Abdulrahman L. Al-Malki
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Experimental Biochemistry Unit, King Fahd Medical Research Center
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Bioactive Natural Products Research Group
Mahmoud Alhosin
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Medical Research Center
Tadao Asami
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Medical Research Center
Graduate School of Agricultural and Life Sciences, The University of Tokyo

Keywords: cancer, phytohormones, synthetic SL analogues, GR24, MEB55, ST362, anti-cancer, apoptosis

JOURNAL FREE ACCESS FULL-TEXT HTML

2018 Volume 43 Issue 3 Pages 168-172

DOI https://doi.org/10.1584/jpestics.D17-090

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Abstract

Chemotherapy shows some promising results in the inhibition of cancer, but resistance to chemotherapy and its severe side effects may occur in due course, resulting in only restricted and narrow benefits. Therefore, there is a pressing need to find alternative chemotherapeutic drugs for combating cancers. Plants have been used since ages in medicine, and by the dawn of 19th century, various potent and promising anti-cancer products have been derived from plants. Strigolactones (SLs) are a novel class of phytohormones involved in regulating the branching of shoots. Recently, many novel synthesized SL analogues have been found to be effective against solid and non-solid tumours. These hormones have been reported to have a unique mechanism of inhibiting cancer cells by lowering their viability and promoting apoptosis and cell death at micromolar concentrations. Therefore, synthetic SL analogues could be future potent anti-cancer drug candidates. Further research is needed to identify and deduce the significance of these synthetic SL analogues.

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