Primäres malignes Melanom im Gehirn eines 7 Monate alten Schafs (Ovis aries f. domestica)

 

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Zusammenfassung

Vorgestellt wird ein bislang nicht beschriebener Fall eines malignen Melanoms im Gehirn eines Schafs. Ein wegen Ataxie euthanasiertes, erst 7 Monate altes, weibliches Schaf wurde pathologisch-anatomisch und histopathologisch untersucht. Sowohl das Gehirn als auch das Schädeldach waren von einem malignen Melanom infiltriert. Metastasen fanden sich in Leber und Nieren. Auch histomorphologisch zeigte das Melanom die Charakteristika einer malignen Neoplasie. Die kongenitale Ansammlung von Melanozyten in der Hirnhaut des Schafs (kongenitale Melanose) ist eine regelmäßig beobachtete Pigmentanomalie, die sich im vorliegenden Fall als Ausgangspunkt des Melanoms anbietet. Das geringe Alter des vorgestellten Tieres legt diesen Zusammenhang nahe. In Fällen von diagnostisch unklaren Erkrankungen sollte auch bei landwirtschaftlichen Nutztieren einschließlich des Schafs ein neoplastisches Geschehen differenzialdiagnostisch in Betracht gezogen werden.

Summary

A case of malignant melanoma in a sheep‘s brain is described for the first time. In a 7-month-old sheep that had been euthanized due to ataxia, post-mortem and histopathologic examinations were performed. Both the brain and the calvarium were heavily infiltrated with neoplastic tissue. Metastases were found in the liver and kidneys. Histomorphology confirmed the gross pathologic impression of malignancy. Congenital melanosis, which is regularly present in the meninx of sheep, could have been the origin of the malignant melanoma in the present case. The young age of the animal appears to favour this supposition. This case demonstrates that even in farm animals – including sheep – a neoplasm should be considered as a differential diag nosis in diagnostically doubtful cases.

• Literatur

• 1 Ahmed IH, Helal IE, Al-Sobayil FA, Mehana EE. Adenoma and adenocarcinoma in sheep and goats. Suez Canal Vet Med J 2007; 12: 279-290.
  PubMedGoogle Scholar
• 2 Ahmed IH, Mohammed MS, Al-Sobayil FA, Mehana EE. Melanoma and malignant melanoma in sheep and goats. Suez Canal Vet Med J 2007; 12: 217-224.
  PubMedGoogle Scholar
• 3 Balakrishnan R, Porag R, Asif DS, Rejaus Satter AM, Taufiq Md, Gaddam SSK. Primary intracranial melanoma with early leptomeningeal spread: a case report and treatment options available. Hindawi Case Rep Oncol Med. 2015 http://dx.doi.org/10.1155/2015/293802
  CrossrefPubMedGoogle Scholar
• 4 Canpolat I, Yaman I, Gunay C. A case of primary intraocular malignant iris melanoma in an Akkaraman sheep. Revue Méd Vét 2007; 158: 171-173.
  PubMedGoogle Scholar
• 5 Cantile C, Youssef S. Nervous system. In: Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. 6th edn.. Maxie MG. ed. St. Louis: Elsevier; 2016: 250-406.
  Google Scholar
• 6 Cordes DO, Shortridge EH. Neoplasms of sheep: a survey of 256 cases recorded at Ruakura Animal Health Laboratory. N Z Vet J 1971; 19: 55-64.
  CrossrefPubMedGoogle Scholar
• 7 Cotchin E. Spontaneous tumours in young animals In: Malignant tumours in children. 1975 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1864054/pdf/procrsmed00039–0087.pdf
  PubMedGoogle Scholar
• 8 Fankhauser R, Luginbühl H. Zentrales Nervensystem. In: Handbuch der speziellen pathologischen Anatomie der Haustiere. Band 3. Dobberstein J, Pallaske G, Stünzi H. Hrsg. Berlin: Parey; 1968: 191-436.
  Google Scholar
• 9 Feldman WH. A report of fourty tumors of sheep (Ovis aries, Jordan). J Cancer 1931; 15: 2044-2062.
  PubMedGoogle Scholar
• 10 Geisel O, Wiest J. Melanosis maculosa und malignes Melanom bei einem Rind. Berl Münch Tierärztl Wschr 1970; 83: 418-420.
  PubMedGoogle Scholar
• 11 Goldgeier MH, Klein LE, Klein-Angerer S, Moellmann G, Nordlund JJ. The distribution of melanocytes in the leptomeninges of human brain. J Invest Dermatol 1984; 83: 235-238.
  PubMedGoogle Scholar
• 12 Goldschmidt MH. Benign and malignant melanocytic neoplasms of domestic animals. Am J Dermatopathol 1985; 7 (Suppl): 203-212.
  PubMedGoogle Scholar
• 13 Koestner A, Higgins RJ. Tumors of the nervous system. In: Tumors in Domestic Animals. 4th edn.. Meuten DJ. ed. Iowa: Iowa State Press; 2002: 697-738.
  Google Scholar
• 14 Makin GW, Eden OB, Lashford LS, Moppett J, Gerrard MP, Davies HA, Powell AN, Campbell AN, Child HF. Leptomeningeal melanoma in childhood. Cancer 1999; 878-886.
  PubMedGoogle Scholar
• 15 Myers RK, McGavin MD, Zachary JE. Cellular adaptations, injury, and death: morphologic, biochemical, and genetic bases. In: Pathologic Basis of Veterinary Disease. 5th edn.. Zachary JF, McGavin MD. eds. St. Louis: Elsevier Mosby; 2012: 2-59.
  Google Scholar
• 16 Ross AD. Studies on neoplasms of sheep – with emphasis on adenocarcinoma of the small intestine. Dissertation Lincoln College, University of Canterbury; New Zealand.:
  Google Scholar
• 17 Scott DW. Neoplastic diseases. In: Large Animal Dermatology. Pedersen D. ed. Philadelphia: Saunders; 1988: 448-452 (Zitiert nach 18).
  Google Scholar
• 18 Smith SH, Goldschmidt MH, McManus PM. A comparative review of melanocytic neoplasms. Vet Pathol 2009; 39: 651-678.
  PubMedGoogle Scholar
• 19 Thomas AJ, Erickson CA. The making of a melanocyte: the specification of melanoblasts from the neural crest. Pigment Cell Melanoma Res 2008; 21: 598-610.
  CrossrefPubMedGoogle Scholar
• 20 Vala H, Pópulo H, Mesquita JR, Esteves F, Santos C, Soares P, Lopes JM. Melanocytic tumour in a Black Sheep never exposed to ultraviolet radiation. J Comp Pathol 2012; 146: 160-164.
  CrossrefPubMedGoogle Scholar
• 21 Weiss E, Rudolph R. Atmungsorgane. In: Grundriss der speziellen pathologischen Anatomie der Haustiere. 6. Aufl.. Dahme E, Weiss E. Hrsg. Stuttgart: Enke; 2007: 49-81.
  Google Scholar
• 22 Wiebe DE, Rang H. Malignes Melanom beim Schaf. Tierärztl Umsch 1978; 33: 676-678.
  PubMedGoogle Scholar
• 23 Wohlsein P, Deschl U, Baumgärtner W. Nonlesions, unusual cell types, and postmortem artifacts in the central nervous system of domestic animals. Vet Pathol 2013; 50: 122-143.
  CrossrefPubMedGoogle Scholar
• 24 Zachary JF. Nervous system. In: Pathologic Basis of Veterinary Disease. 5th edn.. Zachary JF, McGavin MD. eds. St. Louis: Elsevier Mosby; 2012: 771-870.
  Google Scholar