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Effects of poly(para-dioxanone-co-L-lactide) on the in vitro hydrolytic degradation behaviors of poly(L-lactide)/poly(para-dioxanone) blends

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Abstract

Poly(L-lactide)/poly(para-dioxanone) (PLLA/PPDO) (85/15 w/w) blends with 0, 1, 3, and 5 wt% poly(para-dioxanone-co-L-lactide) (PDOLLA) as a compatibilizer were prepared by solution coprecipitation. The in vitro hydrolytic degradation (HD) of blend bars with different contents of PDOLLA was studied by immersing the bars in a phosphate buffer solution (PBS) at pH 7.49. To estimate the degradation of blend bars, the weight loss, water absorption, thermal properties, surface morphology, and mechanical properties of blend bars, as well as the pH value changes of the PBS, were studied for 8 wk of HD. By adding 1 and 3 wt% PDOLLA, the weight loss of PLLA/PPDO (85/15 w/w) blends increased from 6.4 to 6.8 and 7.4% after 8 wk of HD, 6.2 and 15.6% increment, respectively, while, the average tensile strength of PLLA/PPDO (85/15 w/w) blends for 2–8 wk of HD increased from 25.8 to 29.0 MPa and 31.0 MPa, 12.4 and 20.2% increment, respectively. Considering their good mechanical properties and HD rate, the PLLA/PPDO (85/15 w/w) blends with 1 and 3 wt% PDOLLA are potential to be used as a medical implant material.

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ACKNOWLEDGMENTS

This work was supported by grants from the National Natural Science Foundation of China (51103156) and the West Light Foundation of The Chinese Academy of Sciences.

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Authors and Affiliations

  1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, People’s Republic of China

    Xulong Xie, Wei Bai, Dongliang Chen & Chengdong Xiong

  2. University of Chinese Academy of Sciences, Beijing, 100049, People’s Republic of China

    Xulong Xie

  3. Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong, 637009, People’s Republic of China

    Congming Tang

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  1. Xulong Xie
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Correspondence to Wei Bai.

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Xie, X., Bai, W., Tang, C. et al. Effects of poly(para-dioxanone-co-L-lactide) on the in vitro hydrolytic degradation behaviors of poly(L-lactide)/poly(para-dioxanone) blends. Journal of Materials Research 30, 860–868 (2015). https://doi.org/10.1557/jmr.2015.31

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