Skip to main content
SpringerLink
Log in

Bioactive Glass Paste in Molars of Mini-Pigs: An In Vivo Study

  • Published:
MRS Online Proceedings Library Aims and scope

Abstract

Bioactive glass powder in the MgO-CaO-P2O5-SiO2 system was mixed with water to create a bioactive glass paste. The paste was then placed in 8 cavities in molars of Sinclair mini-pigs, isolated using a light-cure composite filling, and left in vivo for 4 weeks. Additionally, 4 controls were run where the bioactive glass was placed in an inert polymer substrate and then incubated at 37°C for 4 weeks. Specimens were cut longitudinally in two halves and prepared for chemical and x-ray analyses. Qualitative results showed that the paste in the molars stayed intact while there was little or no paste left in the polymer substrate after cutting. This observation suggested that the paste in the natural tissue had structural integrity which could be caused by chemical changes and/or mineralization encouraged by contact with dentinal tubule fluid. X-ray analysis did not reveal any crystallinity in the paste at 4 weeks, but chemical alterations were confirmed by electron microprobe analysis. The chemical inhomogeneity of the individual elemental maps revealed the formation of Ca-P-rich/Si-poor areas. These distinct chemical variations were not seen in chemical analyses run on the bioactive glass paste in its initial state.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. Otsuka, M. Sawada, Y. Matsuda, T. Nakamura, T. Kokubo. Antibiotic Delivery System using Bioactive Bone Cement consisting of Bis-GMA/TEGDMA Resin and Bioactive Glass Ceramics. Biomaterials 18:1559–1564 (1997).

    Article  CAS  Google Scholar 

  2. H. Oonishi, S. Kushitani, E. Yasukawa, H. Iwaki, L. Hench, J. Wilson, E. Tsuji, T. Sugihara. Particulate Bioglass compared with Hydroxyapatite as a Bone Graft Substitute. Clin Ortho and Related Res 334: 316–325 (1997).

    Article  Google Scholar 

  3. K. Kudo, M. Miyasawa, Y. Fujioka, T. Kamegai, H. Nakano, Y. Seino, F. Ishikawa, T. Shioyama, K. Ishibashi. Clinical Application of Dental Implant with Root of Coated Bioglass: short-term results. Oral Surg Oral Med Oral Path 70: 18–23 (1990).

    Article  CAS  Google Scholar 

  4. B. Oguntebi, A. Clark, J. Wilson. Pulp Capping with Bioglass and Autologous Demineralized Dentin in Miniature Swine. J Dent Res 72: 484–489 (1993).

    Article  CAS  Google Scholar 

  5. L. Hench. Bioceramics: from Concept to Clinic. J Am Ceram Soc 74: 1487–1510 (1991).

    Article  CAS  Google Scholar 

  6. L. Hench, H. Paschall. Direct Chemical Bond of Bioactive Glass-Ceramic Material to Bone and Muscle. J Biomed Mater Res Symposium 4: 25–42 (1973).

    Article  Google Scholar 

  7. T. Kokubo, S. Ito, Z. Huang, T. Hayashi, S. Sakka, T. Kitsugi, T. Yamamuro. Ca, P-rich Layer formed on High-Strength Bioactive Glass-Ceramic AW. J Biomed Mater Res 24: 331–343 (1990).

    Article  CAS  Google Scholar 

  8. T. Kokubo, H. Kushitani, C. Ohtsuki, S. Sakka. Chemical Reaction of Bioactive Glass and Glass-Ceramics with a Simulated Body Fluid. J Mat Sci 3:79–83 (1992).

    CAS  Google Scholar 

  9. T. Kitsugi, T. Yamamuro, T. Nakamura, T. Kokubo. Bone Bonding Behavior of MgO-CaO-SiO2-P2O5-CaF2 Glass (mother glass of AW-glass-ceramics). J Biomed Mater Res 23: 631–648 (1989).

    Article  CAS  Google Scholar 

  10. S.E. Efflandt, P. Magne, W.H. Douglas, L.F. Francis. The Bonding of Bioactive Glasses to Human Dentin, Proceedings of the 11th International Symposium on Ceramics in Medicine, ed. R.Z. LeGeros and J.P. LeGeros (World Scientific, 1998) pp. 571–574.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, 55455, USA

    Sarah E. Efflandt & Lorraine F. Francis

  2. Department of Oral Sciences, University of Minnesota, Minneapolis, MN, 55455, USA

    Manuela Lopes, Ching-Chang Ko & William H. Douglas

  3. Department of Restorative Sciences, University of Minnesota, Minneapolis, MN, 55455, USA

    Jorge Perdigao

Authors
  1. Sarah E. Efflandt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Manuela Lopes
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ching-Chang Ko
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jorge Perdigao
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. William H. Douglas
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Lorraine F. Francis
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Efflandt, S.E., Lopes, M., Ko, CC. et al. Bioactive Glass Paste in Molars of Mini-Pigs: An In Vivo Study. MRS Online Proceedings Library 662, 24 (2000). https://doi.org/10.1557/PROC-662-LL2.4

Download citation

  • Published:

  • DOI: https://doi.org/10.1557/PROC-662-LL2.4

Search

Navigation