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Active Polymer Nanoparticles: Delivery of Antibiotics

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Abstract

Antibiotic-encapsulated PLA and PLGA nanoparticles were prepared by the single emulsion-solvent evaporation technique. Different PLA and PLGA systems were prepared, varying the copolymer composition and the amount of the surfactant polyvinyl alcohol. Characterization and drug loading studies were performed by UV-Visible spectrophotometry, dynamic light scattering, and scanning electron microscopy (SEM).

Simultaneously, in order to model the diffusion of the nanoparticles within the osteoblast, QDs such as functionalized InGaP/ZnS and polymer encapsulated InGaP/ZnS nanoparticles were added to confluent cultures of primary mouse osteoblasts. Following PreFer fixation, cultures were examined via confocal microscopy. QDs were clearly visible within osteoblasts.

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Authors and Affiliations

  1. Polymer Nanotechnology Lab.at Center for Optoelectronics and Dept. of Chemistry, University of North Carolina at Charlotte, 9201 University City Blvd., 358 GRIGG Hall, Charlotte, NC, 28223, USA

    Monica Rabinovich, Rajeev Raghavan Pillai & Kenneth E. Gonsalves

  2. Department of Biology, University of North Carolina at Charlotte, 9201 University City Blvd., 257 Woodward Hall, Charlotte, NC, 28223, USA

    Shankari N. Somayaji & Michael C. Hudson

  3. Department of Orthopaedic Surgery, Carolinas Medical Center, 1616 Scott Ave., Charlotte, NC, 28203, USA

    J. Kent Ellington & Michael Bosse

  4. Department of Internal Medicine, Carolinas Medical Center, 1000 Blythe Blvd., Charlotte, NC, 28232, USA

    James Horton

Authors
  1. Monica Rabinovich
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  2. Shankari N. Somayaji
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  3. Rajeev Raghavan Pillai
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  4. Michael C. Hudson
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  5. J. Kent Ellington
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  6. Michael Bosse
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  7. James Horton
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  8. Kenneth E. Gonsalves
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Rabinovich, M., Somayaji, S.N., Pillai, R.R. et al. Active Polymer Nanoparticles: Delivery of Antibiotics. MRS Online Proceedings Library 1019, 506 (2007). https://doi.org/10.1557/PROC-1019-FF05-06

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  • DOI: https://doi.org/10.1557/PROC-1019-FF05-06

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