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Detection of Bacillus Anthracis Spores Using Magnetostrictive Microcantilever-based Biosensor

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Abstract

Recently, the magnetostrictive microcantilever (MSMC) as a high performance biosensor platform was introduced. The MSMC is a wireless acoustic wave (AW) sensor and exhibits a high Q value. More importantly, the MSMC works well in liquid. In this paper, the detection of Bacillus anthracis spores using MSMCs with filamentous phage as the bioprobe is reported. The phage-coated MSMC biosensors were exposed to cultures containing target spores with increasing concentrations ranging from 5 × 104 to 5 × 108 spores/mL. By monitoring the shift in the resonance frequency of the MSMCs, the spores were detected in a real-time manner and a detection limit of 105 spores/mL was obtained for the MSMCs used in this research. Higher sensitivity is expected for the MSMCs with smaller size.

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Authors and Affiliations

  1. Materials Research and Education Center, Auburn University, AL, 36849, Auburn, USA

    Liling Fu, Suiqiong Li, Kewei Zhang & Z. Y. Cheng

Authors
  1. Liling Fu
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  2. Suiqiong Li
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  3. Kewei Zhang
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  4. Z. Y. Cheng
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Fu, L., Li, S., Zhang, K. et al. Detection of Bacillus Anthracis Spores Using Magnetostrictive Microcantilever-based Biosensor. MRS Online Proceedings Library 951, 504 (2006). https://doi.org/10.1557/PROC-0951-E05-04

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  • DOI: https://doi.org/10.1557/PROC-0951-E05-04

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