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Magnetic Resonance Imaging (MRI) of Water Diffusion in 2-Hydroxyethyl Methacrylate (HEMA) Gels

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Abstract

A fundamental study focusing on correlating the local water self-diffusion coefficient to the local free water content in 2-hydroxyethyl methacrylate (HEMA) gels was conducted. HEMA gels were synthesized with different nominal water content (50to 90%). MRI measurements of local diffusion coefficient distribution and local water content profiles are conducted on a 600 MHz scanner. The local water content is measured via two spin-echo images with sufficiently long repetition time (TR) to eliminate T1-weighting and two values for the echo time (TE) in order to account for T2-weighting. The local diffusion coefficient is determined using a standard pulsed-field gradient spin-echo sequence. The measured local water content and diffusion coefficient data are compared with several single-parameter diffusion models for interstitial diffusion in the hydrogel (Makie-Meares, Stokes-Einstein, Brownian motion around overlapping spheres).

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Authors and Affiliations

  1. Mechanical Engineering, University of Illnois at Urbana-Champaign, 1206 West Green Street, 140MEB, MC-244, 61801, Urbana, IL, USA

    Guy Raguin, V. Falkenberg Cibele, Shaurya Prakash, R. FitzHenry Heather, Glennys Mensing, G. Georgiadis John & A. Shannon Mark

  2. Beckman Institute for Advanced Science and Technology, University of Illnois at Urbana-Champaign, Biomedical Imaging Center, 2100 S Goodwin Ave, 61801, Urbana, IL, USA

    Luisa Ciobanu

  3. Beckman Institute for Advanced Science and Technology, 405 North Mathews Avenue, 61801, Urbana, IL, USA

    G. Georgiadis John

Authors
  1. Guy Raguin
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  2. V. Falkenberg Cibele
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  3. Shaurya Prakash
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  4. R. FitzHenry Heather
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  5. Glennys Mensing
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  6. Luisa Ciobanu
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  7. G. Georgiadis John
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  8. A. Shannon Mark
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Raguin, G., Cibele, V.F., Prakash, S. et al. Magnetic Resonance Imaging (MRI) of Water Diffusion in 2-Hydroxyethyl Methacrylate (HEMA) Gels. MRS Online Proceedings Library 930, 405 (2006). https://doi.org/10.1557/PROC-0930-JJ04-05

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  • DOI: https://doi.org/10.1557/PROC-0930-JJ04-05

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