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CPT Encapsulated Silica-titania Hollow Nanoparticle Targeting SK-BR-3 Cells for efficient Anticancer treatment

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Abstract

HER-conjugated hollow nanoparticles (HER-HNP, ca. 50 nm in diameter) are fabricated using a dissolution and re-deposition method and used to encapsulate camptothecin (CPT). The HER-HNP-CPT is used as an anti-cancer agent for human breast cancer SK-BR-3. It has excellent mono-dispersity and a high loading efficiency for CPT. Two kind of cell lines are used in this study; SK-BR-3 and RAW 264.7. SK-BR-3 and RAW 264.7 are used as targeting and controlling cell line, respectively. When SK-BR-3 cells are treated with HER-HNP-CPT, the viability decreased to 55%, which is ca. 1.5 times higher anti-cancer efficiency in comparison to RAW 264.7. The HER-HNP-CPT system offers a new opportunity to facilitate implementation of a hydrophobic drug for effective anti-cancer treatment of SK-BR-3 cells.

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Authors and Affiliations

  1. Chemical Convergence for Energy & Environment (C2E2,) School of Chemical and Biological Engineering, College of Engineering, Seoul National University (SNU), Seoul, Korea

    Yoonsun Jang & Jyongsik Jang

Authors
  1. Yoonsun Jang
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  2. Jyongsik Jang
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Jang, Y., Jang, J. CPT Encapsulated Silica-titania Hollow Nanoparticle Targeting SK-BR-3 Cells for efficient Anticancer treatment. MRS Online Proceedings Library 1725, 35–40 (2014). https://doi.org/10.1557/opl.2015.166

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  • DOI: https://doi.org/10.1557/opl.2015.166

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