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Electro-Optical Detection of Single Nanoparticles on a Nanopore-Optofluidic Chip

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Abstract

A solid-state nanopore was integrated into an optofluidic sensor chip, liquid-core anti-resonant reflecting optical waveguide (ARROW). The solid-state nanopore worked as a smart gate, which simultaneously provided characteristic electrical signals and controlled the entry of single nanoparticles into the liquid-core channel. The subsequent fluorescence detection further identified the nanoparticles by providing optical signals within a specific wavelength range. In this work, correlated electrical and optical detection of single nanoparticles, H1N1 viruses, and λ-DNA molecules was demonstrated. Different types of particles in a mixture were successfully discriminated. Moreover, the flow velocity in the liquid-core channel was extracted with the help of combined analysis of electrical and optical signals. Enhanced electrical sensitivity using a solid-state nanopore with a thin limiting aperture sculpted by SiO2 deposition was also shown.

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References

  1. C. Dekker, Nat. Nanotechnol. 2, 209 (2007).

    Article  CAS  Google Scholar 

  2. S. Howorka and Z.S. Siwy, Nat. Biotechnol. 30, 506 (2012).

    Article  CAS  Google Scholar 

  3. B.M. Venkatesan and R. Bashir, Nat. Nanotechnol. 6, 615 (2011).

    Article  CAS  Google Scholar 

  4. A. Chen, M.M. Eberle, E.J. Lunt, S. Liu, K. Leake, M.I. Rudenko, A.R. Hawkins, and H. Schmidt, Lab. Chip 11, 1502 (2011).

    Article  CAS  Google Scholar 

  5. M.I. Rudenko, S. Kühn, E.J. Lunt, D.W. Deamer, A.R. Hawkins, and H. Schmidt, Biosens. Bioelectron. 24, 3258 (2009).

    Article  CAS  Google Scholar 

  6. J.W. Parks, H. Cai, L. Zempoaltecatl, T.D. Yuzvinsky, K. Leake, A.R. Hawkins, and H. Schmidt, Lab. Chip 13, 4118 (2013).

    Article  CAS  Google Scholar 

  7. D. Ozcelik, B.S. Phillips, J.W. Parks, P. Measor, D. Gulbransen, A.R. Hawkins, and H. Schmidt, Lab. Chip 12, 3728 (2012).

    Article  CAS  Google Scholar 

  8. J.W. Parks, H. Cai, L. Zempoaltecatl, T.D. Yuzvinsky, K. Leake, A.R. Hawkins, and H. Schmidt, Lab. Chip 13, 4118 (2013).

    Article  CAS  Google Scholar 

  9. J.W. Parks, M.A. Olson, J. Kim, D. Ozcelik, H. Cai, Jr., J.L. Patterson, R.A. Mathies, A.R. Hawkins, and H. Schmidt, Biomicrofluidics 8, 054111 (2014).

    Article  CAS  Google Scholar 

  10. S. Liu, Y. Zhao, J.W. Parks, D.W. Deamer, A.R. Hawkins, and H. Schmidt, Nano Lett. 14, 4816 (2014).

    Article  CAS  Google Scholar 

  11. J.B. Heng, A. Aksimentiev, C. Ho, P. Marks, Y.V. Grinkova, S. Sligar, K. Schulten, and G. Timp, Nano Lett. 5, 1883 (2005).

    Article  CAS  Google Scholar 

  12. L. Wu, H. Liu, W. Zhao, L. Wang, C. Hou, Q. Liu, and Z. Lu, Nanoscale Res. Lett. 9, 140 (2014).

    Article  CAS  Google Scholar 

  13. M. Wanunu, W. Morrison, Y. Rabin, A.Y. Grosberg, and A. Meller, Nat. Nanotechnol. 5, 160 (2010).

    Article  CAS  Google Scholar 

  14. S. Liu, T.D. Yuzvinsky, and H. Schmidt, ACS Nano 7, 5621 (2013).

    Article  CAS  Google Scholar 

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Acknowledgments

We acknowledge support by the W.M. Keck Center for Nanoscale Optofluidics at University of California, Santa Cruz, the NSF under grants CBET-1402848 and CBET-1402880, and the NIH under grants R01EB006097 and R21EB008802. J.W.P. acknowledges support by the Eugene Cota-Robles Fellowship and the National Science Foundation Graduate Fellowship Research Program under Grant No. DGE 0809125.

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Authors and Affiliations

  1. School of Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA

    Shuo Liu, Joshua W. Parks & Holger Schmidt

  2. Department of Electrical & Computer Engineering, Brigham Young University, 459 Clyde Building, Provo, UT, 84602, USA

    Yue Zhao, Matthew Stott & Aaron R. Hawkins

Authors
  1. Shuo Liu
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  2. Yue Zhao
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  3. Matthew Stott
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  4. Joshua W. Parks
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  5. Aaron R. Hawkins
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  6. Holger Schmidt
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Liu, S., Zhao, Y., Stott, M. et al. Electro-Optical Detection of Single Nanoparticles on a Nanopore-Optofluidic Chip. MRS Online Proceedings Library 1720, 17–22 (2014). https://doi.org/10.1557/opl.2014.954

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  • DOI: https://doi.org/10.1557/opl.2014.954

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