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Bioactive paper: Biomolecule immobilization methods and applications in environmental monitoring

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Abstract

Bioactive paper, or paper that exhibits biorecognition properties, is a promising tool for on-site environmental monitoring. A critical parameter for production of paper-based sensors is the immobilization of biomolecules onto paper with retention of long-term activity. High loading, control over biomolecule orientation and accessibility, and protection of biomolecules from external denaturation need to be provided by the immobilization technique. We present here a summary of the current strategies for enzyme, antibody, bacteriophage, and aptamer immobilization on cellulose and provide examples of the application of bioactive paper in environmental monitoring.

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Acknowledgements

The authors thank the Natural Sciences and Engineering Research Council of Canada and the Sentinel—Canadian Network for the Development and Use of Bioactive Paper for funding.

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Authors and Affiliations

  1. Department of Chemistry and Chemical Biology, McMaster University, USA

    Clémence Sicard & John D. Brennan

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  1. Clémence Sicard
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  2. John D. Brennan
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Correspondence to Clémence Sicard.

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Sicard, C., Brennan, J.D. Bioactive paper: Biomolecule immobilization methods and applications in environmental monitoring. MRS Bulletin 38, 331–334 (2013). https://doi.org/10.1557/mrs.2013.61

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  • DOI: https://doi.org/10.1557/mrs.2013.61

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