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Novel infection-resistant surface coatings: A bioengineering approach

  • All Together Now: Integrating Biofilm Research Across Disciplines
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Abstract

Despite modern advancements in sterilization and aseptic procedures, bacterial infections remain a major and significant impediment to the long-term success of medical implants and devices, including catheters, artificial prosthetics, and subcutaneous sensors. It has been estimated that upward of 60% of nosocomial, or hospital-acquired, infections are associated with implants, with an estimated one million cases per year in the United States alone. Current treatment regimens primarily rely on the systemic administration of antibiotics or local administration through irrigation of the surgical site. However, after decades of prophylactic antibiotic use, high infection rates continue to persist, particularly with the emergence of drug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA). Consequently, recent research efforts have focused on the use of non-antibiotic-based coatings to inhibit bacteria colonization and subsequent biofilm formation on implant surfaces. In particular, advancements in surface treatment strategies and ongoing development of new antimicrobial agents have led to encouraging progress in the design of better coatings. Here, we present and discuss representative examples of novel surface engineering approaches to address device-associated infections, focusing in particular on coatings that can be easily administered onto implant material surfaces.

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References

  1. R.O. Darouiche, N. Engl. J. Med. 350, 1422 (2004).

    Google Scholar 

  2. J.W. Costerton, P.S. Stewart, E.P. Greenberg, Science 284, 1318 (1999).

    Google Scholar 

  3. W.M.J. Dunne, Clin. Microbiol. Rev. 15, 155 (2002).

    Google Scholar 

  4. J.D. Whitehouse, N.D. Friedman, K.B. Kirkland, W.J. Richardson, D.J. Sexton, Infect. Control Hosp. Epidemiol. 23, 183 (2002).

    Google Scholar 

  5. P. Davis, Nurs. Times 99, 46 (2003).

    Google Scholar 

  6. M. Sims, M. Saleh, Prof. Nurse 11, 261 (1996).

    Google Scholar 

  7. M.H.A. Malik, P. Harwood, P. Diggle, S.A. Khan, J. Bone Joint Surg. Br. 86B, 556 (2004).

  8. J.G. Hendriks, J.R. van Hornm, H.C. van der Meim, H.J. Busscherm, Biomaterials 25, 545 (2004).

    Google Scholar 

  9. D.C. Vinh, J.M. Embil, J. Long-Term Eff. Med. Implants 15, 467 (2005).

    Google Scholar 

  10. A.L. Panlilio, D.H. Culver, R.P. Gaynes, S. Banerjee, T.S. Henderson, J.S. Tolson, W.J. Martone, Infect. Control Hosp. Epidemiol. 13, 582 (1992).

    Google Scholar 

  11. K. Hiramatsu, H. Hanaki, T. Ino, K. Yabuta, T. Oguri, F.C. Tenover, J. Antimicrob. Chemother. 40, 2 (1997).

    Google Scholar 

  12. T.L. Smith, M.L. Pearson, K.R. Wilcox, C. Cruz, M.V. Lancaster, B. Robinson-Dunn, F.C. Tenover, M.J. Zervos, J.D. Band, E. White, W.R. Jarvis, N. Engl. J. Med. 340, 493 (1999).

    Google Scholar 

  13. H.W. Buchholz, H. Engelbrecht, Chirurg 41, 511 (1970).

    Google Scholar 

  14. V. Alt, A. Bitschnau, J. Osterling, A. Sewing, C. Meyer, R. Kraus, S.A. Meissner, S. Wenisch, E. Domann, R. Schnettler, Biomaterials 27, 4627 (2006).

    Google Scholar 

  15. M. Lucke, G. Schmidmaier, S. Sadoni, B. Wildemann, R. Schiller, N.P. Haas, M. Raschke, Bone 32, 521 (2003).

    Google Scholar 

  16. C.S. Adams, V. Antoci, Jr., G. Harrison, P. Patal, T.A. Freeman, I.M. Shapiro, J. Parvizi, N.J. Hickok, S. Radin, P. Ducheyne, J. Orthop. Res. 27, 701 (2009).

    Google Scholar 

  17. V. Antoci, C. Adams, N. Hickok, I. Shapiro, Clin. Orthop. Relat. Res. 461, 88 (2007).

    Google Scholar 

  18. A. Valentin, Jr., B.K. Samuel, J. Binoy, P. Javad, R.Z. Allen, W. Eric, A.F. Theresa, J.C. Russell, D. Paul, M.S. Irving, J.H. Noreen, S.A. Christopher, J. Orthop. Res. 25, 858 (2007).

    Google Scholar 

  19. V. Antoci, Jr., C.S. Adams, J. Parvizi, H.M. Davidson, R.J. Composto, T.A. Freeman, E. Wickstrom, P. Ducheyne, D. Jungkind, I.M. Shapiro, N.J. Hickok, Biomaterials 29, 4684 (2008).

    Google Scholar 

  20. H. van de Belt, D. Neut, W. Schenk, J.R. van Horn, H.C. van der Mei, H.J. Busscher, Acta Orthop. Scand. 72, 557 (2001).

    Google Scholar 

  21. L. Zhao, P.K. Chu, Y. Zhang, Z. Wu, J. Biomed. Mater. Res. B: Appl. Biomater. 91B, 470 (2009).

  22. T.J. Berger, J.A. Spadaro, S.E. Chapin, R.O. Becher, Antimicrob. Agents Chemother. 9, 357 (1976).

    Google Scholar 

  23. B.J. Nablo, T.-Y. Chen, M.H. Schoenfisch, J. Am. Chem. Soc. 123, 9712 (2001).

    Google Scholar 

  24. I.A. Rojas, J.B. Slunt, D.W. Grainger, J. Controlled Release 63, 175 (2000).

    Google Scholar 

  25. T. Nuryastuti, H.C. van der Mei, H.J. Busscher, S. Iravati, A.T. Aman, B.P. Krom, Appl. Environ. Microbiol. 75, 6850 (2009).

    Google Scholar 

  26. S.L. Percival, P.G. Bowler, D. Russell, J. Hosp. Infect. 60, 1 (2005).

    Google Scholar 

  27. A. Melaiye, W.J. Youngs, Expert Opin. Ther. Patents 15, 125 (2005).

    Google Scholar 

  28. J. Hardes, H. Ahrens, C. Gebert, A. Streitbuerger, H. Buerger, M. Erren A. Gunsel, C. Wedemeyer, G. Saxler, W. Winkelmann, G. Gosheger, Biomaterials 28. 2869 (2007).

  29. M. Bosetti, A. Masse, E. Tobin, M. Cannas, Biomaterials 23, 887 (2002).

    Google Scholar 

  30. G. Gosheger, J. Hardes, H. Ahrens, A. Streitburger, H. Buerger, M. Erren, A. Gunsel, F.H. Kemper, W. Winkelmann, C. von Eiff, Biomaterials 25, 5547 (2004).

    Google Scholar 

  31. A. Ewald, S. Gluckermann, R. Thull, U. Gbureck, Biomed. Eng. Online 5, 22 (2006).

    Google Scholar 

  32. T. Bechert, M. Boswald, S. Lugauer, A. Regenfus, J. Greil, J.P. Guggenbichler, Infection 27, 24 (1999).

    Google Scholar 

  33. I. Raad, R. Darouiche, R. Hachem, M. Mansouri, G.P. Bodey, The Broad-Spectrum Activity and Efficacy of Catheters Coated with Minocycline and Rifampin (University of Chicago Press, Chicago, IL, ETATS-UNIS, 1996), Vol. 173.

  34. R.E. Gilbert, M. Harden, Curr. Opin. Infect. Dis. 21, 235 (2008).

    Google Scholar 

  35. S. Inouye, T. Takizawa, H. Yamaguchi, J. Antimicrob. Chemother. 47, 565 (2001).

    Google Scholar 

  36. Y. Inoue, A. Shiraishi, T. Hada, K. Hirose, H. Hamashima, J. Shimada, FEMS Microbiol. Lett. 237, 325 (2004).

    Google Scholar 

  37. F. Gomes, P. Teixeira, J. Azeredo, R. Oliveira, Curr. Microbiol. 59, 118 (2009).

    Google Scholar 

  38. K. Bazaka, M.V. Jacob, V.K. Truong, F. Wang, W.A.A. Pushpamali, J.Y. Wang, A.V. Ellis, C.C. Berndt, R.J. Crawford, E.P. Ivanova, Biomacromolecules 11, 2016 (2010).

    Google Scholar 

  39. X. Wang, S. Qiu, X. Yao, T. Tang, K. Dai, Z.A. Zhu, J. Orthop. Res. 27, 1487 (2009).

    Google Scholar 

  40. H.-H. Yu, K.-J. Kim, J.-D. Cha, H.-K. Kim, Y.-E. Lee, N.-Y. Choi, Y.-O. You, J. Med. Food 8, 454 (2005).

    Google Scholar 

  41. R.E. Hancock, D.S. Chapple, Antimicrob. Agents Chemother. 43, 1317 (1999).

    Google Scholar 

  42. H.G. Boman, Annu. Rev. Immunol. 13, 61 (1995).

    Google Scholar 

  43. H. Komatsuzawa, K. Ouhara, S. Yamada, T. Fujiwara, K. Sayama, K. Hashimoto, M. Sugai, J. Pathol. 208, 249 (2006).

    Google Scholar 

  44. M. Zasloff, Nature 415, 389 (2002).

    Google Scholar 

  45. S.L. Haynie, G.A. Crum, B.A. Doele, Antimicrob. Agents Chemother. 39, 301 (1995).

    Google Scholar 

  46. D. Liu, S. Choi, B. Chen, R.J. Doerksen, D.J. Clements, J.D. Winkler, M.L. Klein, W.F. DeGrado, Angew. Chem. Int. Ed. 43, 1158 (2004).

    Google Scholar 

  47. B.P. Mowery, S.E. Lee, D.A. Kissounko, R.F. Epand, R.M. Epand,B.Weisblum, S.S. Stahl, S.H. Gellman, J. Am. Chem. Soc. 129, 15474 (2007).

    Google Scholar 

  48. G.N. Tew, D. Liu, B. Chen, R.J. Doerksen, J. Kaplan, P.J. Carroll, M.L. Klein, W.F. DeGrado, Proc. Natl. Acad. Sci. U.S.A. 99, 5110 (2002).

    Google Scholar 

  49. G.N. Tew, R.W. Scott, M.L. Klein, W.F. DeGrado, Acc. Chem. Res. 43, 30 (2009).

    Google Scholar 

  50. Z. Shi, K.G. Neoh, E.T. Kang, W. Wang, Biomaterials 27, 2440 (2006).

    Google Scholar 

  51. E.M. Hetrick, M.H. Schoenfisch, Biomaterials 28, 1948 (2007).

    Google Scholar 

  52. B.J. Nablo, A.R. Rothrock, M.H. Schoenfisch, Biomaterials 26, 917 (2005).

    Google Scholar 

  53. J. Lin, S. Qiu, K. Lewis, A.M. Klibanov, Biotechnol. Progr. 18, 1082 (2002).

    Google Scholar 

  54. B. Gottenbos, H.C. van der Mei, F. Klatter, P. Nieuwenhuis, H.J. Busscher, Biomaterials 23, 1417 (2002).

    Google Scholar 

  55. J.C. Tiller, C.-J. Liao, K. Lewis, A.M. Klibanov, Proc. Natl. Acad. Sci. U.S.A. 98, 5981 (2001).

    Google Scholar 

  56. J.C. Tiller, S.B. Lee, K. Lewis, A.M. Klibanov, Biotechnol. Bioeng. 79, 465 (2002).

    Google Scholar 

  57. D. Campoccia, L. Montanaro, C.R. Arciola, Biomaterials 27, 2331 (2006).

    Google Scholar 

  58. S.E. Tebbs, A. Sawyer, T.S.J. Elliott, Br. J. Anaesth. 72, 587 (1994).

    Google Scholar 

  59. R.L. Taylor, J. Verran, G.C. Lees, A.J.P. Ward, J. Mater. Sci. - Mater. Med. 9, 17 (1998).

    Google Scholar 

  60. Y. Wu, J.P. Zitelli, K.S. TenHuisen, X. Yu, M.R. Libera, Biomaterials 32, 951 (2011).

    Google Scholar 

  61. J. Verran, C.J. Maryan, J. Prosthetic Dentistry 77, 535 (1997).

    Google Scholar 

  62. R.J. Koerner, L.A. Butterworth, I.V. Mayer, R. Dasbach, H.J. Busscher, Biomaterials 23, 2835 (2002).

    Google Scholar 

  63. B. Del Curto, M.F. Brunella, C. Giordano, M.P. Pedeferri, V. Valtulina, L. Visai, A. Cigada, Int. J. Artif. Organs 28, 718 (2005).

    Google Scholar 

  64. W.-K. Liu, S.E. Tebbs, P.O. Byrne, T.S.J. Elliott, J. Infect. 27, 261 (1993).

    Google Scholar 

  65. G. Harkes, J. Feijen, J. Dankert, Biomaterials 12, 853 (1991).

    Google Scholar 

  66. J.M. Yang, H.T. Lin, T.H. Wu, C.-C. Chen, J. Appl. Polym. Sci. 90, 1331 (2003).

    Google Scholar 

  67. J.N. Baumgartner, C.Z. Yang, S.L. Cooper, Biomaterials 18, 831 (1997).

    Google Scholar 

  68. H.C. Van Der Mei, A.J. Léonard, A.H. Weerkamp, P.G. Rouxhet, H.J. Busscher, Colloids Surf. 32, 297 (1988).

    Google Scholar 

  69. W.G. Pitt, R.N. Morris, M.L. Mason, M.W. Hall, Y. Luo, G.D. Prestwich, J. Biomed. Mater. Res. A 68A, 95 (2004).

  70. M. Morra, C. Cassineli, J. Biomater. Sci., Polym. Ed. 10, 1107 (1999).

    Google Scholar 

  71. M.R. Ruggieri, P.M. Hanno, R.M. Levin, Reduction of Bacterial Adherence to Catheter Surface with Heparin (Elsevier, New York, NY, ETATS-UNIS, 1987), Vol. 138.

  72. A. Abu El-Asrar, A. Shibl, K. Tabbara, S. Al-Kharashi, Int. Ophthalmol. 21, 71 (1997).

    Google Scholar 

  73. P. Appelgren, U. Ransjo, L. Bindslev, F. Espersen, O. Larm, Crit. Care Med. 24, 1482 (1996).

    Google Scholar 

  74. D. Lange, C.N. Elwood, K. Choi, K. Hendlin, M. Monga, B.H. Chew, J. Urol. 182, 1194 (2009).

    Google Scholar 

  75. M.J. Bridgett, M.C. Davies, S.P. Denyer, P.R. Eldridge, Biomaterials 14, 184 (1993).

    Google Scholar 

  76. M.M. Tunney, S.P. Gorman, Biomaterials 23, 4601 (2002).

    Google Scholar 

  77. S.E. Tebbs, T.S.J. Elliott, Eur. J. Clin. Microbiol. Infect. Dis. 13, 111 (1994).

    Google Scholar 

  78. K. Glasmästar, C. Larsson, F. Höök, B. Kasemo, J. Colloid Interface Sci. 246, 40 (2002).

    Google Scholar 

  79. P. Kingshott, H.J. Griesser, Curr. Opin. Solid State Mater. Sci. 4, 403 (1999).

    Google Scholar 

  80. B.D. Ratner, B.S.J., Biomaterials 6, 1417 (2002).

    Google Scholar 

  81. S.K. Hendricks, C. Kwok, M. Shen, T.A. Horbett, B.D. Ratner, J.D. Bryers, J. Biomed. Mater. Res. 50, 160 (2000).

    Google Scholar 

  82. M. Shen, Y.V. Pan, M.S. Wagner, K.D. Hauch, D.G. Castner, B.D. Ratner, T.A. Horbett, J. Biomater. Sci., Polym. Ed. 12, 961 (2001).

    Google Scholar 

  83. T.M. Blättler, S. Pasche, M. Textor, H.J. Griesser, Langmuir 22, 5760 (2006).

    Google Scholar 

  84. M. Heuberger, T. Drobek, N.D. Spencer, Biophys. J. 88, 495 (2005).

    Google Scholar 

  85. Y. Mori, S. Nagaoka, H. Takiuchi, T. Kikuchi, N. Noguchi, H. Tanzawa, Y. Noishiki, ASAIO J. 28, 459 (1982).

    Google Scholar 

  86. A. Roosjen, J. de Vries, H.C. van der Mei, N. Willem, H.J. Busscher, J. Biomed. Mater. Res. B: Appl. Biomater. 73B, 347 (2005).

  87. A. Roosjen, H.C. van der Mei, H.J. Busscher, W. Norde, Langmuir 20, 10949 (2004).

    Google Scholar 

  88. K.D. Park, Y.S. Kim, D.K. Han, Y.H. Kim, E.H.B. Lee, H. Suh, K.S. Choi, Biomaterials 19, 851 (1998).

    Google Scholar 

  89. P. Kingshott, J. Wei, D. Bagge-Ravn, N. Gadegaard, L. Gram, Langmuir 19, 6912 (2003).

    Google Scholar 

  90. G.P. Lopez, B.D. Ratner, C.D. Tidwell, C.L. Haycox, R.J. Rapoza, T.A. Horbett, J. Biomed. Mater. Res. 26, 415 (1992).

    Google Scholar 

  91. A.R. Denes, E.B. Somers, A.C.L. Wong, F. Denes, J. Appl. Polym. Sci. 81, 3425 (2001).

    Google Scholar 

  92. R.G. Chapman, E. Ostuni, M.N. Liang, G. Meluleni, E. Kim, L. Yan, G. Pier, H.S. Warren, G.M. Whitesides, Langmuir 17, 1225 (2001).

    Google Scholar 

  93. E.O. Ostuni, R.G. Chapman, M.N. Liang, G. Meluleni, G. Pier, D.E. Ingber, G.M. Whitesides, Langmuir 17, 6336 (2001).

    Google Scholar 

  94. S. Hou, E.A. Burton, K.A. Simon, D. Blodgett, Y.Y. Luk, D. Ren, Appl. Environ. Microbiol. 73, 4300 (2007).

    Google Scholar 

  95. Z. Yang, J.A. Galloway, H. Yu, Langmuir 15, 8405 (1999).

    Google Scholar 

  96. J.D. Cox, M.S. Curry, S.K. Skirboll, P.L. Gourley, D.Y. Sasaki, Biomaterials 23, 929 (2002).

    Google Scholar 

  97. J.L. Dalsin, B.H. Hu, B.P. Lee, P.B. Messersmith, J. Am. Chem. Soc. 125, 4253 (2003).

    Google Scholar 

  98. J.H. Waite, M.L. Tanzer, Science 212, 1038 (1981).

    Google Scholar 

  99. M. Yu, J. Hwang, T.J. Deming, J. Am. Chem. Soc. 121, 5825 (1999).

    Google Scholar 

  100. J.L. Dalsin, L. Lin, S. Tosatti, J. Voros, M. Textor, P.B. Messersmith, Langmuir 21, 640 (2005).

    Google Scholar 

  101. R. Ko, P.A. Cadieux, J.L. Dalsin, B.P. Lee, C.N. Elwood, H. Razvi, J. Endourol. 22, 1153 (2008).

    Google Scholar 

  102. X. Fan, L. Lin, P.B. Messersmith, Biomacromolecules 7, 2443 (2006).

    Google Scholar 

  103. H. Lee, K.D. Lee, K.B. Pyo, S.Y. Park, H. Lee, Langmuir 26, 3790 (2010).

    Google Scholar 

  104. J.A. Neff, K.D. Caldwell, P.A. Tresco, J. Biomed. Mater. Res. 40, 511 (1998).

    Google Scholar 

  105. J.A. Neff, P.A. Tresco, K.D. Caldwell, Biomaterials 20, 2377 (1999).

    Google Scholar 

  106. M.R. Nejadnik, H.C. van der Mei, H.J. Busscher, W. Norde, Appl. Environ. Microbiol. 74, 916 (2008).

    Google Scholar 

  107. V.A. Liu, W.E. Jastromb, S.N. Bhatia, J. Biomed. Mater. Res. 60, 126 (2002).

    Google Scholar 

  108. K. Vacheethasanee, R.E. Marchant, J. Biomed. Mater. Res. 50, 302 (2000).

    Google Scholar 

  109. L.G. Harris, S. Tosatti, M. Wieland, M. Textor, R.G. Richards, Biomaterials 25, 4135 (2004).

    Google Scholar 

  110. R.R. Maddikeri, S. Tosatti, M. Schuler, S. Chessari, M. Textor, R.G. Richards, L.G. Harris, J. Biomed. Mater. Res. A 84, 425 (2008).

    Google Scholar 

  111. G. Subbiahdoss, B. Pidhatika, G. Coullerez, M. Charnley, R. Kuijer, H.C. van der Mei, M. Textor, H.J. Busscher, Eur. Cells Mater. 19, 205 (2010).

    Google Scholar 

  112. M. Billinger, F. Buddeberg, J.A. Hubbell, D.L. Elbert, T. Schaffner, D. Mettler, S. Windecker, B. Meier, O.M. Hess, Polymer Stent Coating for Prevention of Neointimal Hyperplasia (HMP Communications, Wayne, PA, 2006), Vol. 18, pp. 4.

  113. M. Sarikaya, C. Tamerler, A.K.J. Jen, K. Schulten, F. Baneyx, Nat. Mater. 2, 577 (2003).

    Google Scholar 

  114. K.I. Sano, K. Shiba, J. Am. Chem. Soc. 125, 14234 (2003).

    Google Scholar 

  115. S.R. Meyers, P.T. Hamilton, E.B. Walsh, D.J. Kenan, M.W. Grinstaff, Adv. Mater. 19, 2492 (2007).

    Google Scholar 

  116. A.B. Sanghvi, K.P.H. Miller, A.M. Belcher, C.E. Schmidt, Nat. Mater. 4, 496 (2005).

    Google Scholar 

  117. X. Huang, S. Zauscher, B. Klitzman, G.A. Truskey, W.M. Reichert, D.J. Kenan, M.W. Grinstaff, Ann. Biomed. Eng. 38, 1965 (2010).

    Google Scholar 

  118. D.J. Kenan, E.B. Walsh, S.R. Meyers, G.A. O’Toole, E.G. Carruthers, W.K. Lee, S. Zauscher, C.A.H. Prata, M.W. Grinstaff, Chem. Biol. 13, 695 (2006).

    Google Scholar 

  119. E. Koivunen, W. Arap, D. Rajotte, J. Lahdenranta, R. Pasqualini, J. Nucl. Med. 40, 883 (1999).

    Google Scholar 

  120. G.S. Nowakowski, M.S. Dooner, H.M. Valinski, A.M. Mihaliak, P.J. Quesenberry, P.S. Becker, Stem Cells 22, 1030 (2004).

    Google Scholar 

  121. D.A. Rothenfluh, H. Bermudez, C.P. O’Neil, J.A. Hubbell, Nat. Mater. 7, 248 (2008).

    Google Scholar 

  122. B.K. Kay, J. Winter, J. McCafferty, Phage Display of Peptides and Proteins (Academic Press, San Diego, 1996).

    Google Scholar 

  123. R.H. Hoess, Chem. Rev. 101, 3205 (2001).

    Google Scholar 

  124. G.P. Smith, V.A. Petrenko, Chem. Rev. 97, 391 (1997).

    Google Scholar 

  125. G. Smith, Science 228, 1315 (1985).

    Google Scholar 

  126. E.B. Walsh, C. Middleton, M.J. Davis, D.J. Kenan, M.W. Grinstaff, ACS Div. Polym. Chem. 43, 753 (2002).

    Google Scholar 

  127. X. Khoo, P. Hamilton, G.A. O’Toole, B.D. Snyder, D.J. Kenan, M.W. Grinstaff, J. Am. Chem. Soc. 131, 10992 (2009).

    Google Scholar 

  128. X. Khoo, G.A. O’Toole, S.A. Nair, B.D. Snyder, D.J. Kenan, M.W. Grinstaff, Biomaterials 31, 9285 (2010).

    Google Scholar 

  129. S.R. Meyers, X. Khoo, X. Huang, E.B. Walsh, M.W. Grinstaff, D.J. Kenan, Biomaterials 30, 277 (2009).

    Google Scholar 

  130. T. Kacar, M.T. Zin, C. So, B. Wilson, H. Ma, N. Gul-Karaguler, A.K. Jen, M. Sarikaya, C. Tamerler, Biotechnol. Bioeng. 103, 696 (2009).

    Google Scholar 

  131. E.A. Scott, M.D. Nichols, L.H. Cordova, B.J. George, Y.S. Jun, D.L. Elbert, Biomaterials 29, 4481 (2008).

    Google Scholar 

  132. J. Kim, B.K. Wacker, D.L. Elbert, Biomacromolecules 8, 3682 (2007).

    Google Scholar 

  133. J.P. Bearinger, D.G. Castner, S.L. Golledge, A. Rezania, S. Hubchak, K.E. Healy, Langmuir 13, 5175 (1997).

    Google Scholar 

  134. N.P. Desai, S.F.A. Hossainy, J.A. Hubbell, Biomaterials 13, 417 (1992).

    Google Scholar 

  135. G.M. Harbers, K. Emoto, C. Greef, S.W. Metzger, H.N. Woodward, J.J. Mascali, D.W. Grainger, M.J. Lochhead, Chem. Mater. 19, 4405 (2007).

    Google Scholar 

  136. I.C. Saldarriaga Fernández, H.C.v.d. Mei, S. Metzger, D.W. Grainger, A.F. Engelsman, M.R. Nejadnik, H.J. Busscher, Acta Biomater. 6, 1119 (2009).

    Google Scholar 

  137. F. Boulmedais, B. Frisch, O. Etienne, P. Lavalle, C. Picart, J. Ogier, J.C. Voegel, P. Schaaf, C. Egles, Biomaterials 25, 2003 (2004).

    Google Scholar 

  138. L. Richert, P. Lavalle, E. Payan, X.Z. Shu, G.D. Prestwich, J.-F. Stoltz, P. Schaaf, J.-C. Voegel, C. Picart, Langmuir 20, 448 (2003).

    Google Scholar 

  139. O. Etienne, C. Picart, C. Taddei, Y. Haikel, J.L. Dimarcq, P. Schaaf, J.C. Voegel, J.A. Ogier, C. Egles, Antimicrob. Agents Chemother. 48, 3662 (2004).

    Google Scholar 

  140. Z. Li, D. Lee, X. Sheng, R.E. Cohen, M.F. Rubner, Langmuir 22, 9820 (2006).

    Google Scholar 

  141. S.Pavlukhina, Y. Lu,A. Patimetha,M. Libera,S. Sukhishvili,Biomacromolecules, 11 (12), 3448 (2010).

  142. B.-S. Kim, S.W. Park, P.T. Hammond, ACS Nano 2, 386 (2008).

    Google Scholar 

  143. W. Yuan, J. Ji, J. Fu, J. Shen, J. Biomed. Mater. Res. B: Appl. Biomater. 85B, 556 (2008).

  144. S.M. Olsen, L.T. Pedersen, M.H. Laursen, S. Kiil, K. Dam-Johansen, Biofouling: J. Bioadhesion Biofilm Res. 23, 369 (2007).

    Google Scholar 

  145. I. Francolini, G. Donelli, FEMS Immunol. Med. Microbiol. 59, 227 (2010).

    Google Scholar 

  146. H.-C. Flemming, J. Wingender, T. Griebe, C. Mayer, Chapter 2: Physicochemical properties of biofilms. Biofilms: Recent Advances in Their Study and Control L. Evans, Ed., (Harwood Academic Publishers, Amsterdam, 2000), pp. 19–34.

  147. S. Rotem, A. Mor, Biochimica et Biophysica Acta (BBA)— Biomembranes 1788 (8), 1582–1592 (2009).

    Google Scholar 

  148. H. Tang, T. Cao, X. Liang, A. Wang, S.O. Salley, J. McAllisterII, K.Y.S. Ng, Journal of Biomedical Materials Research Part A 88A (2), 454–463 (2009).

    Google Scholar 

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Acknowledgements

We thank the National Institutes of Health (Grant No. AR054872-01) for support. MWG has a conflict of interest, as he is co-founder of Affinergy Inc.—a start-up company that has an interest in device coatings.

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  1. Boston University, MA, 02215, USA

    Xiaojuan Khoo & Mark W. Grinstaff

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  1. Xiaojuan Khoo
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  2. Mark W. Grinstaff
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Correspondence to Xiaojuan Khoo.

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Khoo, X., Grinstaff, M.W. Novel infection-resistant surface coatings: A bioengineering approach. MRS Bulletin 36, 357–366 (2011). https://doi.org/10.1557/mrs.2011.66

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