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Adhesion and interfacial fracture in drug-eluting stents

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Abstract

This paper presents experimental and theoretical studies of the adhesion between the drug-eluting layer and a Parylene C primer layer in coatings present on a model drug-eluting stent. To quantify adhesion, Brazil nut sandwich specimens were prepared mimicking the layers of this coating. These samples were stressed to fracture, and the resulting initial cracks at the Parylene C/drug interface were used to measure the dependence of interfacial fracture energy of mode mixity. The mating fracture surfaces were then analyzed using scanning electron microscopy (SEM) and energy dispersive x-ray spectroscopy (EDX). The interfacial energy release rates were obtained over a wide variety of mode mixities. Adhesion and fracture mechanics models were then used to estimate the mode mixity dependency of interfacial fracture toughness. Fracture toughness was found to be larger under higher mode mixity than that under lower mixity and the analytical model showed close agreement with experimental results.

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Authors and Affiliations

  1. Princeton Institute of Science and Technology of Materials, and the Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey, 08544, USA

    Juan Meng & Ting Tan

  2. Cordis Corporation, A Johnson and Johnson Company, Spring House, Pennsylvania, 19446, USA

    Argjenta Orana, Kurt Wolf, Hannah Li & George Papandreou

  3. Department of Civil and Environmental Engineering, University of Massachusetts–Dartmouth, North Dartmouth, Massachusetts, 02747, USA

    Nima Rahbar

  4. Cordis Corporation, A Johnson and Johnson Company, Warren, New Jersey 07059, USA

    Cynthia Maryanoff

  5. Cordis Corporation, A Johnson and Johnson Company, Spring House, Pennsylvania, 19446, USA

    Wole Soboyejo

Authors
  1. Juan Meng
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  2. Argjenta Orana
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  3. Ting Tan
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  4. Kurt Wolf
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  5. Nima Rahbar
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  6. Hannah Li
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  7. George Papandreou
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  8. Cynthia Maryanoff
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  9. Wole Soboyejo
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Corresponding author

Correspondence to Wole Soboyejo.

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Meng, J., Orana, A., Tan, T. et al. Adhesion and interfacial fracture in drug-eluting stents. Journal of Materials Research 25, 641–647 (2010). https://doi.org/10.1557/JMR.2010.0097

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  • DOI: https://doi.org/10.1557/JMR.2010.0097

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