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Reduced-Intensity Conditioning Allogeneic Stem Cell Transplantation for Multiple Myeloma: Results from the Japan Myeloma Study Group

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Abstract

We conducted a retrospective survey of multiple myeloma (MM) patients who underwent reduced-intensity conditioning allogeneic stem cell transplantation (RIST) at 11 hospitals participating in the Japan Myeloma Study Group. Forty-five patients (median age, 53 years) were included in this study. The conditioning regimen consisted of a fludarabine-based regimen in 24 patients and a regimen based on total body irradiation (1–2 Gy) in 18 patients. Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine and tacrolimus in 28 and 17 patients, respectively. All patients showed myeloid engraftment. Complete chimerism was obtained in 42 patients. Grade II to IV acute GVHD developed in 28 (65%) of 43 patients evaluated, and chronic GVHD developed in 31 (76%) of 41 patients. Early death before day 100 was observed in 4 patients (8.8%). A complete response (CR) was obtained in 12 patients. The factors affecting overall survival were severe acute GVHD and the response after RIST. To date, 18 patients are alive, with 9 patients remaining in CR at a median follow-up of 25 months. The overall and progression-free survival rates at 3 years were 38.5% and 18.8%, respectively. These observations suggest that RIST is feasible with reliable donor engraftment and relatively low transplantation-related mortality in Japanese MM patients.

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Authors and Affiliations

  1. Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, 602-8566, Kamigyoku, Kyoto, Japan

    Chihiro Shimazaki

  2. Department of Hematology, Kyoto First Red Cross Hospital, Kyoto

    Hiroshi Fujii

  3. Department of Medicine, Toyama Prefectural Central Hospital, Toyama

    Takashi Yoshida

  4. Department of Medicine, Niigata Cancer Center Hospital, Niigata

    Takaaki Chou

  5. Second Department of Medicine, Chiba University School of Medicine, Chiba

    Miki Nishimura

  6. Fourth Department of Internal Medicine, Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital, Hiroshima

    Hideki Asaoku

  7. Department of Hematology, Saiseikai Maehashi Hospital, Maehashi

    Shuichi Miyawaki

  8. Division of Hematology and Oncology, Chiba Cancer Center Hospital, Chiba

    Akihiro Ishii

  9. First Department of Internal Medicine, Sapporo Medical University, Sapporo

    Tadao Ishida

  10. Department of Molecular Genetics and Laboratory Medicine, Kyoto Prefectural University of Medicine, Kyoto

    Masafumi Taniwaki

  11. Department of Hematology and Collagen Disease, Nagoya City University Hospital, Nagoya

    Shinsuke Iida

  12. Japan Myeloma Study Group, Japan

    Toshiyuki Takagi & Kiyoshi Takatsuki

Authors
  1. Chihiro Shimazaki
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  2. Hiroshi Fujii
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  3. Takashi Yoshida
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  4. Takaaki Chou
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  5. Miki Nishimura
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  6. Hideki Asaoku
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  7. Shuichi Miyawaki
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  8. Akihiro Ishii
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  9. Tadao Ishida
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  10. Masafumi Taniwaki
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  11. Shinsuke Iida
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  12. Toshiyuki Takagi
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  13. Kiyoshi Takatsuki
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Shimazaki, C., Fujii, H., Yoshida, T. et al. Reduced-Intensity Conditioning Allogeneic Stem Cell Transplantation for Multiple Myeloma: Results from the Japan Myeloma Study Group. Int J Hematol 81, 342–348 (2005). https://doi.org/10.1532/IJH97.04174

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  • DOI: https://doi.org/10.1532/IJH97.04174

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