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Licensed Unlicensed Requires Authentication Published by De Gruyter September 6, 2018

Progress in research on the role of Omi/HtrA2 in neurological diseases

  • Xiao Juan Su , Lingyi Huang , Yi Qu EMAIL logo and Dezhi Mu

Abstract

Omi/HtrA2 is a serine protease present in the mitochondrial space. When stimulated by external signals, HtrA2 is released into the mitochondrial matrix where it regulates cell death through its interaction with apoptotic and autophagic signaling pathways. Omi/HtrA2 is closely related to the pathogenesis of neurological diseases, such as neurodegeneration and hypoxic ischemic brain damage. Here, we summarize the biological characteristics of Omi/HtrA2 and its role in neurological diseases, which will provide new hints in developing Omi/HtrA2 as a therapeutic target for neurological diseases.

Acknowledgments

This work was supported by the National Key Research Project (grant no. 2017YFA0104200), the National Natural Science Foundation of China (grant nos. 81330016, 81630038, and 81771634), the Science and Technology Project of Sichuan Province (grant no. 2016TD0002), and the National Key Project of Neonatal Children (grant no. 1311200003303). In addition, we would like to thank Edit Age for English language editing.

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Received: 2018-01-21
Accepted: 2018-05-17
Published Online: 2018-09-06
Published in Print: 2019-04-24

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